Background: We sought to compare the effectiveness and safety of sublingual versus vaginal misoprostol for the termination of pregnancy with a live full-term fetus.Methods: This randomized, triple-blind, placebo-controlled clinical trial was performed on 200 primiparous women with normal, singleton, full-term pregnancies candidated for the induction of labor. Sublingual and vaginal tablets cont...

BACKGROUND Spontaneous abortion is categorized as threatened, inevitable, incomplete, complete, or missed. Abortion can be further categorized as sporadic or recurrent. By definition, a missed abortion is an in utero death of the embryo or fetus before the 20th week of gestation with retained conception products. Missed abortions may also be referred to as blighted ovum or an anembryonic pregna...

UNLABELLED SUMMARY QUESTION: Is vaginal progesterone gel equivalent to vaginal micronized progesterone tablets concerning ongoing pregnancy rate and superior concerning patient convenience when used for luteal support after IVF/ICSI? SUMMARY ANSWER Equivalence of treatments in terms of ongoing live intrauterine pregnancy rate has not been demonstrated; the 95% confidence interval (CI) for the...

In this study, a bioadhesive dosage form of clotrimazole was designed using a combination of bioadhesive polymers Carbopol 934P, sodium carboxymethyl cellulose and sodium alginate in different ratios. The bioadhesive strength was evaluated by measuring the force required to detach the tablets from porcine vaginal mucosal membrane. The strong interaction between polymer and mucus lining of the t...

OBJECTIVE To evaluate the effectiveness of vaginal misoprostol in overcoming an unsatisfactory colposcopy in the patients who had abnormal cervical cytology and to evaluate side effects of vaginal misoprostol. METHODS Sixty patients with an unsatisfactory colposcopy during the period of September 2007-November 2008 were recruited and randomly allocated to receive either two tablets of 200 mic...

Objectives: To assess the effectiveness, safety and acceptability of intracervical foley catheter and vaginal misoprostol versus vaginal misoprostol for termination of second trimester pregnancy. Methods: This clinical study was conducted on 200 pregnant patients intended for termination of pregnancy between 13-24 gestational weeks for any indication. Enrolled women were equally allocated into ...