نتایج جستجو برای: valproate

تعداد نتایج: 3279  

2015
Jesper Kofoed Damm Sandra Gordon Mats Ehinger Mats Jerkeman Urban Gullberg Anne Hultquist Kristina Drott

BACKGROUND Epigenetic code modifications by histone deacetylase inhibitors (HDACi) have been proposed as potential new therapies for lymphoid malignancies. Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive lymphoma for which standard first line treatment is the chemotherapy regimen CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) combined with the monoc...

Journal: :Neurology India 2005
Amitav Rath T Jaishree Naryanan G V S Chowdhary J M K Murthy

Hyperammonemic encephalopathy with normal liver function is an uncommon serious adverse effect of valproate therapy. We retrospectively analyzed the case records of 5 patients of epilepsy on valproate with hyperammonemic encephalopathy. Of the 5 patients, 3 were on monotherapy. The mean valproate dose was 1250 mg/day and the duration of therapy ranged between 4 and 90 days. Alteration in the se...

Journal: :Epilepsia 2015
Torbjörn Tomson Anthony Marson Paul Boon Maria Paola Canevini Athanasios Covanis Eija Gaily Reetta Kälviäinen Eugen Trinka

This document provides guidance on the use of valproate in girls and women of childbearing age from a joint Task Force of the Commission on European Affairs of the International League Against Epilepsy (CEA-ILAE) and the European Academy of Neurology (EAN), following strengthened warnings from the Coordination Group for Mutual Recognition and Decentralised Procedures-Human (CMDh) of the Europea...

Journal: :acta medica iranica 0
fahmida ghaderibarmi department of emergency, school of medicine, iran university of medical sciences, tehran, iran. nader tavakkoli department of emergency, school of medicine, iran university of medical sciences, tehran, iran. mansoureh togha department of neurology, school of medicine, tehran university of medical sciences, tehran, iran.

migraine is a common and incapacitating neurologic disorder manifesting with episodic moderate to a severe headache and other symptoms such as photophobia, phonophobia, nausea, and vomiting. triptans and ergot compounds have been used as treatment options for an acute migraine headache for many years. triptans are considered the first line of treatment in patients with moderate to a severe migr...

Journal: :PLoS ONE 2009
Chihiro Kakiuchi Shinsuke Ishigaki Christine M. Oslowski Sonya G. Fonseca Tadafumi Kato Fumihiko Urano

BACKGROUND Valproate is a standard treatment for bipolar disorder and a first-line mood stabilizer. The molecular mechanisms underlying its actions in bipolar disorder are unclear. It has been suggested that the action of valproate is linked to changes in gene expression and induction of endoplasmic reticulum (ER) stress-response proteins. PRINCIPAL FINDINGS Here we show that valproate modula...

2011
Mahmood Khaksary Mahabady Hossien Najafzadeh Varzi

Problem statement: Some reports showed the teratogenic effects of sodium valproate can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Therefore, in this study, the prophylactic effect of melatonin on teratogenic effects of sodium valproate was compared. Approach: This study was performed on 31 pregnant rats that were divided into five groups. Con...

2014
Omar Farooq Pervaiz M. Zunga Mohd I. Dar Abdul Q. Rather Samia Rashid Javid Basu Ishrat H. Dar Mohd Ashraf

A 21-year-old male known case of primary hypothyroidism, Seizure disorder sequelae of an old trauma receiving sodium valproate, clobazam and phenobarbitone for control of Generalized tonic clonic seizures reported to neurology OPD with history of altered sensorium and gait unsteadiness for 1 week with history of hike in valproate dose 2 weeks before. On examination he was drowsy. Neurological e...

Journal: :Hiroshima journal of medical sciences 2013
Akihiko Machino Hiroaki Jitsuiki Yasumasa Okamoto Satoru Izumitani Yasuhiro Kimura Katsuji Suzuki Teruaki Tanaka Takeshi Inoue Tsukasa Koyama Ken Wada Yukari Masaoka Takanobu Sasaki Reiji Yoshimura Jun Nakamura Satsuki Sumitan Tetsuro Ohmori Shigeto Yamawaki

The appropriate therapeutic serum valproate level in maintenance therapy for bipolar disorder is not well known. We studied the serum valproate levels in seventeen bipolar I and twenty-four bipolar II disorder outpatients who had been treated with stable doses of valproate successfully for at least 12 months as prophylactic therapy. The trough serum valproate levels were 52.2 +/- 20.4 microg/ml...

Journal: :Seizure 2001
Line Sveberg RØste Erik TaubØll Aasmund Berner Kjell Andersen Berg Mona Aleksandersen Leif Gjerstad

Uncertainty exists about the effect of antiepileptic drugs on gonadal function. In females, long-term valproate treatment has been shown to induce endocrine disturbances and an increased number of ovarian cysts. The aim of the present study was to investigate whether valproate can also induce morphological changes in the testis of male animals. In addition, possible morphological changes in the...

2013
Edward C. Lauterbach

Psychotropics (antipsychotics, mood stabilizers, antidepressants, anxiolytics, etc.) are commonly prescribed to treat Huntington's disease (HD). In HD preclinical models, while no psychotropic has convincingly affected huntingtin gene, HD modifying gene, or huntingtin protein expression, psychotropic neuroprotective effects include upregulated huntingtin autophagy (lithium), histone acetylation...

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