In biomedical research, researchers frequently use statistical procedures such as the t-test, standard analysis of variance (ANOVA), or the repeated measures ANOVA to compare means between the groups of interest. There are frequently some misuses in applying these procedures since the conditions of the experiments or statistical assumptions necessary to apply these procedures are not fully take...

This article teaches the multivariate analysis of variance (MANOVA) method for repeated measures analysis to researchers who are already familiar with regular analysis of variance (ANOVA) methods. Repeated measures designs are traditionally analyzed with mixed-model ANOVAS. However, sphericity violations markedly affect the true Type I error rates and power for the mixed-model tests. However, t...

This paper is concerned with methods for analyzing quantitative, noncategorical profile data, e.g., a battery of tests given to individuals in one or more groups. It is assumed that the variables have a multinormal distribution with an arbitrary variance-covariance matrix. Approximate procedures based on classical analysis of variance are presented, including an adjustment to the degrees of fre...