Bronchopulmonary dysplasia (BPD), the chronic lung disease associated with preterm birth, results from the disruption of normal pulmonary vascular and alveolar growth. Though BPD was once described as primarily due to postnatal injury from mechanical ventilation and oxygen therapy after preterm birth, it is increasingly appreciated that BPD results from antenatal and perinatal factors that inte...

We report a case of dysplastic arterial vascular abnormality in a 32-year-old man with overlying neuronal cell migration disorder. MR images showed a thickened left insular cortex adjacent to the abnormal vascular network. These findings suggest the possibility of leptomeningeal damage during neuronal cell migration as the cause of the overlying vasculopathy. The true pathogenesis of these seem...

We report the case of a 23-year-old female patient, who was admitted to our hospital because of aggravating pain in the right shoulder, right chest and ear accompanied by cough and dyspnea. Imaging revealed a soft tissue mass in the mediastinum in close relation with an additional large mass extending in the right upper thorax, right axilla and neck. The tissue obtained during surgery showed th...

RATIONALE Inactivating mutations in the Forkhead Box transcription factor F1 (FOXF1) gene locus are frequently found in patients with alveolar capillary dysplasia with misalignment of pulmonary veins, a lethal congenital disorder, which is characterized by severe abnormalities in the respiratory, cardiovascular, and gastrointestinal systems. In mice, haploinsufficiency of the Foxf1 gene causes ...

1. Zimmerman R, Leeds NE, Naidich TP. Carotid-cavernous fistula associated with intracranial fibromuscular dysplasia. Radiology 1977; 122 :725-726 2. Mellinger KL, Ericson K. Fibromuscular dysplasia and the brain: observations on angiographic, clinical and genetic characteristics. Stroke 1982; 13 :4657 3. Bellot J, Gherardi R, Poirier J, Lacour P, Debrun G, Barbizet J. Fibromuscular dysplasia o...

(CIN II), and severe dysplasia or carcinoma in situ (CIN III), depend ing upon the extent of nuclear abnormality and the degree to which the differentiated upper layers of the epithelium are replaced by abnormal cells (8). The lesions differ from cancer in that the abnormal cells are confined to the epithelium and do not transgress the basement mem brane beneath it. Both cervical dysplasia and ...

The presence of coronavirus-associated myocarditis remains controversial despite elevations in cardiac troponin and natriuretic peptide many patients. Aim. To assess the morphological changes myocardium patients who died due to coronavirus disease 2019 (COVID-19) compare them with intravital level biomarkers. Material methods . A total 420 hospital charts 77 autopsies those from COVID-19 were a...

Past studies have primarily focused on how altered lung vascular growth and development contribute to pulmonary hypertension. Recently, basic studies of vascular growth have led to novel insights into mechanisms underlying development of the normal pulmonary circulation and the essential relationship of vascular growth to lung alveolar development. These observations have led to new concepts un...