نتایج جستجو برای: vascular smooth muscle
تعداد نتایج: 581590 فیلتر نتایج به سال:
S mooth muscle cells are important sources of interleukins, chemokines and growth factors in several organ systems. Proinflammatory, mitogenic, and promigratory stimuli produced by vascular and visceral smooth muscle cells may contribute significantly to pathologenesis of atherosclerosis, asthma, inflammatory bowel diseases, and preterm labor. Understanding the role of smooth muscle cells as so...
It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile to the proliferative/synthetic phenotype, has an important role during vascular remodelling and diseases. Here we provide evidence that challenges this theory. We identify a new type of stem cell in the blood vessel wall, named multipotent vascular stem cells. Multipotent vascular stem cells expres...
Tardif K, Hertig V, Duquette N, Villeneuve L, El-Hamamsy I, Tanguay J, Calderone A. Nestin upregulation characterizes vascular remodeling secondary to hypertension in the rat. Am J Physiol Heart Circ Physiol 308: H1265–H1274, 2015. First published March 13, 2015; doi:10.1152/ajpheart.00804.2014.—Proliferation and hypertrophy of vascular smooth muscle cells represent hallmark features of vessel ...
AIM To explore this hypothesis that smooth muscle cells may be capable of acquiring a myofibroblastic phenotype, we have studied the expression of smoothelin in fibrotic conditions. METHODS Normal liver tissue (n = 3) was obtained from macroscopically normal parts of hepatectomy, taken at a distance from hemangiomas. Pathological specimens included post-burn cutaneous hypertrophic scars (n = ...
α-smooth muscle actin, encoded by ACTA2 gene, is an isoform of the vascular smooth muscle actins, typically expressed in the vascular smooth muscle cells contributing to vascular motility and contraction. ACTA2 gene mutations cause a diversity of diffuse vasculopathies such as thoracic aortic aneurysms and dissections as well as occlusive vascular diseases, including premature coronary artery d...
BACKGROUND Administration of general anesthetics to patients with chronic hypertension often causes hemodynamic instability that has been attributed in part to a poorly understood increased loss of control of peripheral vascular smooth muscle tone. The purpose of the current study was to determine if such an increased loss occurs in the spontaneously hypertensive (SH) rat neurogenic model of ch...
OBJECTIVE Actin dynamics in vascular smooth muscle is known to regulate contractile differentiation and may play a role in the pathogenesis of vascular disease. However, the list of genes regulated by actin polymerization in smooth muscle remains incomprehensive. Thus, the objective of this study was to identify actin-regulated genes in smooth muscle and to demonstrate the role of these genes i...
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