Skeletal muscle blood flow is closely coupled to metabolic demand, and its regulation is believed to be mainly the result of the interplay of neural vasoconstrictor activity and locally derived vasoactive substances. Muscle blood flow is increased within the first second after a single contraction and stabilizes within approximately 30 s during dynamic exercise under normal conditions. Vasodila...

1. Sarnoff SJ, Berglund E: Neurohemodynamics of pulmonary edema. IV. Effect of systemic vasoconstriction and subsequent vasodilation on flow and pressures in systemic and pulmonary vascular beds. Am J Physiol 170: 588, 1952 2. Imperial ES, Levy MN, Zieske H Jr: Outflow resistance as an independent determinant of cardiac performance. Circ Res 9: 1148, 1961 3. Sonnenblick EH, Downing SE: Afterloa...

This study was intended to explore the effects of endothelium-independent, direct smooth muscle relaxants(papaverine, verapamil) and endothelium-dependent vasodilators(acetylcholine, bradykinin, adenosine) on the isolated cavernosal smooth muscle strips taken from diabetic men with impotence. When smooth muscle contraction was evoked with norepinephrine for the study of relaxation to these vaso...

The objective of this review is to review the anaesthetic implications of vasoactive compounds particularly with regard to the cerebral circulation and their clinical importance for the practicing anaesthetist. Material was selected on the basis of validity and application to clinical practice and animal studies were selected only if human studies were lacking. Hypotensive drugs have been used ...