Tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. To date, there is no information on the pharmacokinetics of tacrolimus in Iranian liver transplant recipients. This study was designed to determine pharmacokinetic properties of orally administe...

Introduction: Rhopalurus junceus scorpion venom has shown potential for anticancer treatment. However, there are no scientific evidence about venom pharmacokinetic (PK) and biodistribution (BD) in tumor-bearing mice. Methods: 131I-labeled venom was administrated by intravenous (IV) and oral (PO) routes at the single dose of 12.5 mg/kg. Mice were sacrificed and blood samples, major organs, and t...

We study the complexity of graph modification problems with respect to homomorphism-based colouring properties edge-coloured graphs. A homomorphism from $G$ $H$ is a vertex-mapping that preserves adjacencies and edge-colours. consider property having fixed $H$. The question we are interested in is: given an $G$, can perform $k$ operations so resulting admits $H$? vertex-deletion, edge-deletion ...

Tacrolimus, a cornerstone of immunosuppressive therapy in solid organ transplantation, has a narrow therapeutic range with considerable inter-individual and intra-individual pharmacokinetic variability. To date, there is no information on the pharmacokinetics of tacrolimus in Iranian liver transplant recipients. This study was designed to determine pharmacokinetic properties of orally administe...

Hughes has defined a class of groups, which we call FSS (finite similarity structure) groups. Each FSS group acts on a compact ultrametric space by local similarities. The best-known example is Thompson’s group V . Guided by previous work on Thompson’s group V , we establish a number of new results about FSS groups. Our main result is that a class of FSS groups are of type F∞. This generalizes ...

We study the following problem: for given integers d, k and graph G, can we reduce some fixed graph parameter π of G by at least d via at most k graph operations from some fixed set S? As parameters we take the chromatic number χ, clique number ω and independence number α, and as operations we choose the edge contraction ec and vertex deletion vd. We determine the complexity of this problem for...

Plasma pharmacokinetics of ST-246, smallpox therapeutic, was evaluated in mice, rabbits, monkeys and dogs following repeat oral administrations by gavage. The dog showed the lowest Tmax of 0.83 h and the monkey, the highest value of 3.25 h. A 2- to 4-fold greater dose-normalized Cmax was observed for the dog compared to the other species. The mouse showed the highest dose-normalized AUC, which ...

The disposition of 5-fluorouracil (FUra) was studied in 19 colorectal cancer patients dunrng treatment with FUra and high-dose leucovorin (LV) with or without interferon x2a (IFN-a). All received LV 200 mg mIover 2 h. then FUra 400 mg m-2 over 5 min then FUra 400 mgm ' over 22 h. repeated on day 2. on a 14 day cycle. Nine patients also received IFN-a 6 MU every 48 h, starting at least 2 weeks b...

The physiologic dead space/tidal volume ratio (VD/VT) at rest and during exercise is a sensitive measurement of gas exchange that reflects matching of ventilation to perfusion, but requires an invasive measurement for its calculation. Determining VD/VT noninvasively uses estimations of arterial PCO2 based on the end-tidal PCO2. To further standardize incremental cardiopulmonary exercise testing...

Four types of Shiraz inlay (Khatam) samples were impregnated with nano-silver solution via spraying (S), a vacuum desiccator (VD), and immersion/dipping (I/D) for 2 h 24 techniques. The decay resistance dimensional stability evaluated after each treatment. specimens exposed to white-rot fungus 10 weeks by the agar-plate method, weight loss was determined assess decay. soaking in water measured....