s | 49 Aims: This project aims to assess whether systemic treatment with ketamine may improve the behavioural response in an animal model of a treatment resistant condition. Methods: Male Sprague-Dawley rats received subcutaneous injections of ACTH (100ug/rat/day) or vehicle during 14 days. On the 14th day the animals were exposed to the pre-test session of forced swim (FST) and after 24h they ...

Antidepressant drugs modify in different ways the activity of neurons, by increasing monoamines levels and by modulating ion channels. Sodium channels are molecular targets for antiepileptic drugs, which can also be mood stabilizers (i.e. lamotrigine, topiramate, phenytoin, carbamazepine, valproic acid). After a short overview on the sodium channels and the interaction with antidepressants and ...

s | 49 Aims: This project aims to assess whether systemic treatment with ketamine may improve the behavioural response in an animal model of a treatment resistant condition. Methods: Male Sprague-Dawley rats received subcutaneous injections of ACTH (100ug/rat/day) or vehicle during 14 days. On the 14th day the animals were exposed to the pre-test session of forced swim (FST) and after 24h they ...

s | 49 Aims: This project aims to assess whether systemic treatment with ketamine may improve the behavioural response in an animal model of a treatment resistant condition. Methods: Male Sprague-Dawley rats received subcutaneous injections of ACTH (100ug/rat/day) or vehicle during 14 days. On the 14th day the animals were exposed to the pre-test session of forced swim (FST) and after 24h they ...

The purpose of this research was to investigate and improve the accuracy existing slab-track mat (STM) specifications in evaluation vibration reduction effect. static nonlinearity dynamic mechanical characteristics three types STMs were tested, then a modified fractional derivative Poynting–Thomson (FDPT) model used characterize preload frequency dependence. A vehicle–floating slab track (FST) ...

The forced swim test (FST) is commonly employed to test the potency of drugs to reduce immobility as an indicator of anti-despair. Certainly, antidepressant drugs reduce the total time of immobility and enlarge the latency to the first immobility period. FST is preceded by the open field test (OFT) to discard any influence of changes in general motor activity that could interfere with immobilit...

the directional response and roll stability characteristics of a partly filled tractor semi-trailer vehicle, with cylindrical tank, are investigated in various maneuvers. the dynamic interaction of liquid cargo with the tractor semi-trailer vehicle is also evaluated by integrating a dynamic slosh model of the partly filled tank with five-degrees-of-freedom of a tractor semi-trailer tank model. ...

AIM OF THE STUDY Yueju-Wan (YJ), a traditional Chinese medicinal formula, is commonly used for the treatment of depression-related syndromes in China. This study was conducted to evaluate the antidepressant activity of YJ ethanol extract (YJ-E) and its four different fractions, the petroleum ether fraction (YJ-EA), ethyl acetate fraction (YJ-EB), n-butanol fraction (YJ-EC) and final aqueous fra...

This study was designed to investigate the effects of fisetin (FST) on hyperhomocysteinemia (HHcy)-induced experimental endothelial dysfunction (ED) and vascular dementia (VaD) in rats. Wistar rats were randomly divided into 8 groups: control, vehicle control, l-methionine, FST (5, 10, and 25 mg/kg, p.o.), FST-per se (25 mg/kg, p.o.), and donepezil (0.1 mg/kg, p.o.). l-Methionine administration...