Cytotoxic activities of three naturally occurring macrocyclic peptides (cyclotides) isolated from the two violets, Viola arvensis Murr. and Viola odorata L., were investigated. A nonclonogenic fluorometric microculture assay was used to examine cytotoxicity in a panel of 10 human tumor cell lines representing defined types of cytotoxic drug resistance. Additionally, primary cultures of tumor ce...

Background: The present study encompassed a highly traded medicinal plant Viola odorata L. (Violaceae) for detailed Light and Scanning Electron Microscopy, ethnobotany phytochemical evaluation. Phytochemical evaluation included ascorbic acid, nutritional, profile, essential fixed oil study. Even though each feature has its own limited taxonomic value but collectively these characteristics may b...

Objective: Viola odorata has been used since ancient times. According to Traditional Iranian Medicine (TIM) sources, it a cool and moist temperament is for treatment of different diseases. Due the low side effects numerous beneficial this plant, study aims review its therapeutic from perspective TIM modern medicine. Methods: In study, search was conducted materials in many books such as Canon M...

BACKGROUND Insomnia is the most common sleep disorder that reduces quality of life. OBJECTIVES Due to side effects of hypnotic drug and the increasing demand for alternative medicine substitutes, violet oil (VO) was used in this study. VO is a known medication in Iranian traditional medicine that induces sleep in insomniac patients. PATIENTS AND METHODS This study was conducted as an experi...

BACKGROUND As per the recent statistical reports of World Health Organisation (WHO), 13% of total global population is obese. Orlistat remains to be the only drug approved for the long term treatment of obesity. Recent findings highlighted severe adverse effects of orlistat that included hepatotoxicity, gall stones, kidney stones and acute pancreatitis. Therefore, search for new drug is require...

In the present study the antibacterial activity of extracts and pure constituents of V. odorata was evaluated against Mycobacterium tuberculosis H37Rv and clinical isolate of MDR-TB (M. avium, ATCC 25291). Crude ethanol extract of the plant was fractionated with different solvents to yield respective extracts. The n-hexane and Dichloromethane fractions showing good activity against both strains...