Although vitamin E deficiency in ruminants results in conspicuous heart disease, a similar deficiency state in primates appears to spare the heart, even when other systems are affected. No heart disease in man has been related to a vitamin E deficiency. The pharmacologic use of vitamin E in doses 10 to 50 times the daily requirement was recommended in 1947 for the treatment of a variety of card...

the specificity of gentamicin for vitamin e deficiency-associated oxidative stresses in the renal proximal convoluted tubules is apparently related to its ability to increasingly facilitate generation of radical species in mitochondria. to determine the ways in which vitamin e manage the currently processes, we conducted a prospective study aimed to investigate the tubular preserving effect of ...

Inflammatory disorders of the bowel and colon cancer are associated with elevated indices of oxidative stress. Analogous elevations in markers of oxidative stress and loss of cell-membrane integrity are also observed in the colons of rats deficient in vitamin E (D-alpha-tocopherol), the major lipid-soluble antioxidant in biological systems. The causal relationship between colon pathologies asso...

Several recent, reports from this laboratory have implicated vitamin E in the metabolism of the nucleic acids. It was shown that vitamin E-deficient rabbits excrete extra quantities of allantoin (1) and that the livers from such animals exhibit greatly increased xanthine oxidase activities (2). Finally it haa been shown that vitamin E deprivation in the rat, leads to an increased incorporation ...

Vitamin E inhibits oxidative processes in living tissues. We produced vitamin E-deficient mice by feeding them a vitamin E-deficient diet to verify the influence of chronic vitamin E deficiency on cognitive function. We measured cognitive function over a 5-d period using the Morris water maze task, as well as antioxidant enzyme activity and lipid peroxidation in discrete brain regions, and tota...

Several recent, reports from this laboratory have implicated vitamin E in the metabolism of the nucleic acids. It was shown that vitamin E-deficient rabbits excrete extra quantities of allantoin (1) and that the livers from such animals exhibit greatly increased xanthine oxidase activities (2). Finally it haa been shown that vitamin E deprivation in the rat, leads to an increased incorporation ...

We report a case of fat-soluble vitamin deficiency in a 14-year old boy who had chronic duodenal obstruction. He presented with periodic unexplained bleeding tendency. The laboratory results showed positive fat globules in stool and prolonged prothrombin time. His further investigation revealed low plasma vitamin A and undetectable plasma vitamin E. After parenteral vitamin K and oral vitamin A...

The effect of vitamin E on the contact sensitization responses induced in mice by 2,4-dinitrochlorobenzene (DNCB) was studied. Mice were fed a vitamin E-adequate or a vitamin E-deficient diet for 5 weeks. The amounts of thiobarbituric acid-reactive substances in the spleens and draining auricular lymph nodes of mice were decreased by dietary vitamin E. Dietary vitamin E prevented lipid peroxida...

Chronological changes of gonadotropin (FSH and LH) and testosterone concentrations in the serum were measured in vitamin E deficient rats to investigate the effects of vitamin E deficiency on the pituitary-gonadal function in rats. The receptor sites and association constant (Ka) for LH and the formation of cyclic AMP in the Leydig cells were also investigated. The results obtained in the prese...