PURPOSE This study was designed to measure vitamin D metabolites in the aqueous and vitreous humor and in tear fluid, and to determine if dietary vitamin D3 supplementation affects these levels. We also determined if the corneal epithelium can synthesize vitamin D following UV-B exposure. METHODS Rabbits were fed a control or vitamin D3 supplemented diet. Pilocarpine-stimulated tear fluid was...

Partially liquefied vitreous humor is a common physical and biochemical degenerative change in vitreous body which the liquid component gets separated from collagen fiber network and leads to form a region of liquefaction. The main objective of this research is to investigate how the oscillatory motions influence flow dynamics of partial vitreous liquefaction (PVL). So far computational fluid d...

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by post-transcriptional inhibition of mRNA translation. Dysregulation of miRNAs, including circulating miRNAs, has been reported to play an important role in the development of various diseases, including fibrotic diseases. Aberrant expression of miRNAs in the vitreous humor of vitreoretinal diseased eyes has been reporte...

Methods The ocular samples viz., corneal swab, corneal scraping, aqueous tap and vitreous tap were processed for culture and the isolated Nocardia species were further confirmed for speciation by standard microbiological procedures. Antibiotic susceptibility analysis for the confirmed isolates of N. asteroides was performed by agar disk diffusion method following the guidelines of Clinical Labo...

A healthy 34-year-old man presented with Ochrobactrum intermedium endophthalmitis due to a metallic intraocular foreign body. After vitrectomy, lensectomy, removal of the metallic intraocular foreign body, intravitreal vancomycin and ceftazidime, and systemic ciprofloxacin, intraocular inflammation worsened. Repeat vitreous culture confirmed persistent endophthalmitis due to multidrug-resistant...

Purpose To determine the relationship between the different isoforms of apolipoprotein E (ApoE) and retinal neovascularization. Methods The concentrations of ApoE and VEGF in vitreous humor samples with either a macular hole (MH), or diabetic macular edema (DME), or proliferative diabetic retinopathy (PDR) with or without intravitreal injection of bevacizumab (IVB) were measured by ELISA. The...

Purpose Fungal infections post keratoplasty due to contamination of the donor corneal graft have become important issues that need to be addressed. Here we report a case of fungal keratitis and endophthalmitis post penetrating keratoplasty (PKP) due to fungal contamination of the donor corneal graft. Observations We present a 52-year-old male who underwent PKP with a donor corneal graft that ...

INTRODUCTION The causative organism and treatment outcomes of post operative endophthalmitis may vary depending on several factors. OBJECTIVE To find out the causative organisms and visual outcome after an outbreak of post-operative endophthalmitis. MATERIALS AND METHODS An interventional prospective series of cases of clinically suspected endophthalmitis was studied. Eleven patients who pr...

purpose : to investigate the penetration of cefixime and ciprofloxacin to the rabbit eye on the basis of microbial inhibition of aqueous and vitreous humour after oral administration. methods : in this experimental study, 36 rabbits (72 eyes) were randomly divided into two groups group a consisted of 20 rabbits and group b 16 rabbits. each group was divided into four equal subgroups. the rabbit...

To completely avoid ice crystal formation and thus get a higher survival rate, vitrification methods have been commonly used for cryopreservation of oocytes and embryos. However, currently used vitrification methods for oocytes and embryos are not suitable for the cryopreservation of preantral follicles (PFs). In the present study, stainless steel mesh was fabricated into mini mesh cups to vitr...