Introduction Organic isothiocyanates (R-N=C=S) and glucosinolates, their biosynthetic precursors in plants, are attracting increasing attention as chemical and dietary protectors against cancer. More than 20 natural and synthetic isothiocyanates and several glucosinolates have been shown to block chemical carcinogenesis in animal models (see reviews in [1,2]); moreover, these substances are wid...

Abstract Isothiocyanates are biotoxic degradation products formed as a result of enzymatic hydrolysis glucosinolates present in Brassica species. The application biofumigant crops, an alternative crop protection method for soilborne pathogens and pests is increasingly gaining interest. However, little known the potential biofumigation to reduce inoculum Fusarium species affecting cereals. aim t...

Abstract This study aimed to investigate the influence of different thermal treatment methods (boiling, steaming) on metabolome and volatilome Brussels sprouts. Targeted, quantitative analysis primary metabolites (amino acids sugars), glucosinolates as well untargeted volatile organic compounds (VOCs) were performed. The composition was affected only by boiling, where loss nutrients observed. G...

A group of arylalkyl isothiocyanates were tested for their abilities to inhibit tumorigenicity and DNA methylation induced by the esophageal-specific carcinogen, N-nitrosomethylbenzylamine (NMBA) in the F344 rat esophagus. Phenylpropyl isothiocyanate (PPITC) was more potent than either phenylethyl isothiocyanate (PEITC) or benzyl isothiocyanate (BITC). Phenylbutyl isothiocyanate (PBITC), howeve...

Aromatic isothiocyanates are interesting pseudohalides molecules which are widely existed in healthy intact plants. However, few attempts were made to analyze their structures and correlate their electronic structure with other properties (e.g., chemical reactivity). In this paper, the electronic structures and substituent effects of o-, m-, and piodophenyl isothiocyanates were studied by the u...

Cabbage contains the glucosinolate sinigrin, which is hydrolyzed by myrosinase to allyl isothiocyanate. Isothiocyanates are thought to inhibit the development of cancer cells by a number of mechanisms. The effect of cooking cabbage on isothiocyanate production from glucosinolates during and after their ingestion was examined in human subjects. Each of 12 healthy human volunteers consumed three ...

The ring-opening copolymerisation of a d -xylose 3,5-anyhydrosugar with isothiocyanates forms AB-type copolymers imidothiocarbonate linkages. Block copolymer synthesis, reaction kinetics, polymer degradation and metal absorption are explored.

ABSTRACT Isothiocyanates are released through enzymatic degradation of glucosinolates produced by plants in the family Brassicaceae. Glucosinolate profiles differ among plant species and the isothiocyanate derivatives differ in their toxicity to nematodes. Control of plant-parasitic nematodes in soil by isothiocyanates released from incorporated brassicaceous plant material has been inconsisten...

Our preceding papers [1 — 3] referring to the quantitative study of nucleophilic addi­ tion reactions of isothiocyanates (ITC) deal with the reactivity of alkyl and particu­ larly aryl isothiocyanates with —OH ions, amino groups (of various amines and amino acids), and thioglycolate. Results thus obtained together with further analogous ones from investigation of the reactivity of ITC with othe...