The multifunctional Ca(2+)/calmodulin-dependent protein kinase II δ-isoform (CaMKIIδ) promotes vascular smooth muscle (VSM) proliferation, migration, and injury-induced vascular wall neointima formation. The objective of this study was to test if microRNA-30 (miR-30) family members are endogenous regulators of CaMKIIδ expression following vascular injury and whether ectopic expression of miR-30...

Vascular damage signals smooth muscle cells to proliferate, often exacerbating existing pathologies. Although the role of changes in "global" Ca2+ in vascular smooth muscle (VSM) cell dedifferentiation has been studied, the role of specific Ca2+ signals in determining VSM phenotype remains relatively unexplored. Earlier work with cultured VSM cells suggests that inositol 1,4,5-trisphosphate rec...

More than 30% of the US population has high blood pressure (BP), and less than a third of people treated for hypertension have it controlled. In addition, the etiology of most high BP is not known. Having a better understanding of the mechanisms underlying hypertension could potentially increase the effectiveness of treatment. Because G(q) signaling mediates vasoconstriction and vascular functi...

Vascular smooth muscle (VSM) cell migration is a critical step in the development of a neointima after angioplasty. Matrix metalloproteinases (MMPs) degrade the basement membrane and extracellular matrix, facilitating VSM cell migration. Recently, we demonstrated that nitric oxide (NO) inhibits interleukin-1 beta (IL-1 beta)-stimulated MMP-9 induction in rat aortic VSM cells. In this study, we ...

Value Stream Mapping (VSM) is an established technique to model, analyze and optimize material and information flows in a manufacturing company. VSM does supply a graphical notation, however, it does not provide an automatic execution model. As a result, the flows modeled in VSM need to be mapped to executable ITSystems manually. This paper proposes an approach to enable automatic execution of ...

Vector space model (VSM) is a common method for measuring test questions similarity in largescale item bank system. VSM is limited in accurately representing the knowledge relationship and the potential semantic relations of different characteristic words, hence this paper proposes a method of test questions similarity measure called OVSM-TQSM which combines domain ontology and VSM. OVSMTQSM ca...

BACKGROUND Coronary artery disease is today's most important post-heart transplantation problem after the first perioperative year. Histologically, coronary artery disease is characterized by transplant arteriosclerosis. The current view on this vasculopathy is that vascular smooth muscle (VSM) cells from the media of affected arteries proliferate and migrate into the sub-endothelial space (int...

Manufacturing organizations always needs some ways to reduce production lead time, eliminate waste and increase quality to survive in today’s competitive world. Lean manufacturing is such a technique used by industries all over the world in past few decades. It consists of various tools and techniques to reduce waste and increase productivity. One of the major tools in lean manufacturing is Val...

Background—Oxidized LDL reduces NO-mediated and endothelium-derived hyperpolarizing factor–mediated dilations. We studied, in hamster skeletal muscle resistance arteries (21368 mm; n551), whether an altered vascular smooth muscle (VSM) response, particularly sensitization of the VSM contractile apparatus to Ca, is involved in this oxLDL effect. Methods and Results—VSM or endothelial [Ca]i and v...

BACKGROUND Oxidized LDL reduces NO-mediated and endothelium-derived hyperpolarizing factor-mediated dilations. We studied, in hamster skeletal muscle resistance arteries (213+/-8 micrometer n=51), whether an altered vascular smooth muscle (VSM) response, particularly sensitization of the VSM contractile apparatus to Ca(2+), is involved in this oxLDL effect. Methods and Results-VSM or endothelia...