LIM homeobox family members regulate a variety of cell fate choices during animal development. In C. elegans, mutations in the LIM homeobox gene lin-11 have previously been shown to alter the cell division pattern of a subset of the 2 degrees lineage vulval cells. We demonstrate multiple functions of lin-11 during vulval development. We examined the fate of vulval cells in lin-11 mutant animals...

Yaumatei Dermatology Clinic, 12/F, Yaumatei Specialist Clinic, 143 Battery street, Kowloon, Hong Kong A 52-year-old Chinese man with twenty years of psoriasis presented with characteristic cobblestonelike lesions over his legs. Biopsy of the lesions showed pseudo-epitheliomatous hyperplasia typical of elephantiasis nostras verrucosa. This is the first reported case of elephantiasis nostras verr...

OBJECTIVES To examine within the primary health care setting, the frequency of chronic vulval disorders, their frequency, investigation, management and referral patterns. METHODS A questionnaire based survey at general practitioners surrounding a district general hospital. RESULTS A total of 79 (72%) GPs replied to the questionnaire. Thirty-six (45%) GPs saw more than one patient per month ...

SURGICAL TREATMENT OF ELEPHANTIASIS SCROTI COMPLICATED WITH REDUCIBLE SCROTAL HERNIA, 1st BY PERFORMING A MODIFICATION OF WOOD'S OPERATION ON THE HERNIA; AND 2ndlt, BY EXCISION OF THE DISEASED SCROTUM. Case I.? Aheer, u Mahoinedan cultivator, aged 40 years, who Lad long been in bad health, was admitted into Mr. Cntcliffe's ward on the 28th November, 1871, with elephantiasis of the scrotum of tw...

We are using Caenorhabditis elegans vulval induction to study intercellular signaling and its regulation. Genes required for vulval induction include the LIN-3 transforming alpha-like growth factor, the LET-23 epidermal growth factor (EGF)-receptor-like transmembrane tyrosine kinase, the SEM-5 adaptor protein, LET-60 Ras, and the LIN-45 Raf serine/threonine kinase. Inactivation of this pathway ...

BACKGROUND Scrotal lymphedema is rare outside endemic filariasis regions in Africa and Asia. It is of variable origin in the western world. CASE PRESENTATION We present a case of a 40-year-old European man with massive elephantiasis of the scrotum attributed to chronic inflammation of the lower urinary tract caused by urinary outlet obstruction and diabetes mellitus. The patient underwent sub...

Vulval conditions may present to a variety of clinicians, such as dermatologists, gynaecologists and general practitioners. Women with these conditions are best managed by a multidisciplinary approach, which includes clear referral pathways between disciplines or access to a specialist multidisciplinary vulval service. Informed consent is a prerequisite for all examinations, investigations and ...