international travel has become increasingly common and accessible, hence, about two billion passengers undertake international and domestic air travel each year. venous thromboembolism (vte) is a serious public health disorder which may occur following prolonged travel, especially after air travel. a direct relation between vte development and prolonged travels has been documented, while some ...

Venous thromboembolism is a well-known complication of total knee replacement, total hip replacement, and hip fracture repair. Venous thromboembolism, which includes deep vein thrombosis and pulmonary embolism, can cause significant morbidity and mortality. In addition, treatment of this condition can result in substantial costs to the health care system. Patients who have undergone orthopedic ...

In the last few decades many new anticoagulants (i.e direct thrombin and factor ten inhibitors) have been introduced with efficacy that rivals older drugs in the treatment of venous thromboembolism (VTE). However, for all their success, management of patients with recurrent thromboembolic events is still a challenging clinical scenario and not well addressed in the literature. We report the cas...

Venous thromboembolism (VTE) is the cause of significant morbidity and mortality and may lead to other complications, including recurrent VTE and long-term postthrombotic syndrome. Venous thromboembolism represents a huge health economic burden of nearly 500 million dollars/year in the United States. Without adequate prophylaxis, patients undergoing major orthopedic surgery are at high risk of ...

Edoxaban, a factor Xa inhibitor, was approved by the United States Food and Drug Administration in 2015 for stroke prevention in nonvalvular atrial fibrillation and treatment of venous thromboembolism. It is the fourth target-specific oral anticoagulant to be approved. Edoxaban is noninferior for efficacy compared to warfarin for both approved indications. Edoxaban is superior to warfarin for t...

Venous thromboembolism is the third leading cause of vascular death,1 with a high incidence, especially among older persons. Incidence rates increase from 1 per 10,000 annually among persons less than 40 years of age to nearly 1% annually among persons 80 years of age or older2; more than one third of cases occur in persons older than 60 years of age.3 The mainstay of treatment for more than a ...

Venous thromboembolism is a common medical problem. Recently, the emphasis has been on a switch to outpatient low molecular weight heparin therapy. Previous warfarin nomograms have been developed only for inpatients. We prospectively assessed a warfarin initiation nomogram in 105 consecutive outpatients; the nomogram requires International Normalized Ratio (INR) testing on only days 3, 5, and 8...

Objective To determine the safety of direct oral anticoagulant (DOAC) use compared with warfarin use for the treatment of venous thromboembolism.Design Retrospective matched cohort study conducted between 1 January 2009 and 31 March 2016.Setting Community based, using healthcare data from six jurisdictions in Canada and the United States.Participants 59 525 adults (12 489 DOAC users; 47 036 war...

Treatment goals for deep venous thrombosis include stopping clot propagation and preventing the recurrence of thrombus, the occurrence of pulmonary embolism, and the development of pulmonary hypertension, which can be a complication of multiple recurrent pulmonary emboli. About 30 percent of patients with deep venous thrombosis or pulmonary embolism have a thrombophilia. An extensive evaluation...