the quantitative structure–property relationship (qspr) method is used to develop the correlation between structures of crude oil hydrocarbons (80 compounds) and their boiling point and water solubility. sub-structural molecular fragments (smf) calculated from structure alone were used to represent molecular structures. a subset of the calculated fragments selected using stepwise regression (fo...

Water solubility is a key aspect that needs to be addressed to obtain drug-like compounds. In an effort to improve the water solubility of our recently reported nanomolar matrix metalloproteinase type 2 (MMP-2) inhibitors based on triazole-substituted hydroxamates, we synthesized a new series of α-sulfone, α-tetrahydropyran and α-piperidine, α-sulfone clicked hydroxamates and determined their i...

Pendant oligoethyleneglycol groups confer water solubility to a cavitand over a wide pH range. The kinetic stability of the host-guest complexes reveals an effective stabilization through hydrogen bonding even in the highly competitive aqueous environment.

A novel NBD-derived fluorescent probe for Zn(2+) is described; the probe features ready availability, good water solubility, high sensitivity and selectivity, and ability to quantify the concentration of Zn(2+).

the objectives of present investigations were to optimize concentration of oil, surfactant and cosurfactant by pseudoternary phase diagrams and to develop a stable formulation of self emulsifying drug delivery system (sedds) in order to enhance the dissolution rate of poorly soluble irbesartan (ibs) by sedds. pseudoternary phase diagrams were constructed to identify the self emulsifying region....

Solubility of lornoxicam in various pure solvents and solvent-cosolvent mixtures was studied to understand drug vehicle interactions and in order to get the required solubility equal to the dose of lornoxicam, i.e., 4 mg/ml for development of solution formulation. Polyethylene glycol (PEG) 400, propylene glycol, ethanol, water, dimethyl formamide, dimethyl sulfoxide, and ethyl acetate were used...

Amphiphilic cyclodextrin–fullerene conjugates have potential biological activity, due to their water solubility. In order to study the influence of the linker of these conjugates on solubility and aggregation, a permethylated β-cyclodextrin–C60 conjugate with a short linker –(CH2)2NHCO–, which is attached to the secondary face of β-cyclodextrin was synthesized. Its solubility in water and its U...

Responsive polymeric assemblies and hybrid superstructures fabricated from stimuli-sensitive polymers and inorganic nanoparticles (NPs) have been the subject of extensive investigations during the past few decades due to their distinct advantages such as an improved water solubility, stimuli-responsiveness, excellent biocompatibility, and facile introduction of functional units. In addition, th...

Fluorescence labelling of an intracellular biomolecule in native living cells is a powerful strategy to achieve in-depth understanding of the biomolecule's roles and functions. Besides being nontoxic and specific, desirable labelling probes should be highly cell permeable without nonspecific interactions with other cellular components to warrant high signal-to-noise ratio. While it is critical,...

The solubility of naproxen in binary mixtures of polyethylene glycol 200 (PEG 200) + water at the temperature range from 298.0 K to 318.0 K were reported. The combinations of Jouyban-Acree model + van't Hoff and Jouyban-Acree model + partial solubility parameters were used to predict the solubility of naproxen in PEG 200 + water mixtures at different temperatures. Combination of Jouyban-Acree m...