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Intravenous injection of powdered tablets intended to oral use is a common practice among drug abusers, given the greater effectiveness attributed to accelerate delivery of the drug through this route compared to oral intake. This can result in both acute and chronic changes in the pulmonary vessels and parenchyma. Various terms have been used to describe this entity and include self-induced pu...

We report a case of Wegener's granulomatosis clinically mistaken for carcinoma in a 21-year-old girl presenting with an ulcerated mass of the nasopharynx associated with enlarged laterocervical nodes. The lesion was clinically suspected as malignant on the basis of clinical and radiological findings (namely, computed tomography scan and positron emission tomography). However, multiple biopsies ...

36 Hind CR, Winearls CG, Lockwood CM, Rees AJ, Pepys MB. Objective monitoring of activity in Wegener's granulomatosis by protein concentration. Clin Nephrol 1984; 21:341-5. 37 Imbach P. Wegener'sche granulomatose. Ergeb Inn Med Kinderheilkd 1977;39:33-54. 38 Lehmann H, Neidermayer W. Stadienteilung der Wegener'schen granulomatose. Med Welt 1987;38: 466-9. 39 Lehmann H, Keifer B. Clinical manife...

Wegener's granulomatosis is a granulomatous vasculitis that can present with a wide spectrum of clinical manifestations. This disease entity predominantly affects the respiratory tract and the kidneys. Two forms of Wegener's granulomatosis have been recognized: systemic and limited. It has not been established if the two forms represent separate disease entities or different stages of the same ...

Wegener's granulomatosis is a necrotizing vasculitis that may affect any viscera. Gastrointestinal involvement is rather uncommon. We present a case of Wegener's granulomatosis with multiple small bowel ulcers and a single ileal perforation. Histological examination of the surgically resected specimen demonstrated evidence for necrotizing vasculitis. Gross and histological features of the gastr...

The granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a pauci-immune vasculitis involving small- and medium-sized blood vessels. Classically, the patients inflicted with this disease present with a triad of necrotizing granulomatous inflammation of the respiratory tract, cutaneous necrotizing vasculitis, and glomerulonephritis (GN). The antinuclear (ANA) and...

Background: Wegener granulomatosis or granulomatosis with polyangiitis is a pauci-immune small vessel vasculitis which is usually associated with anti-neutrophil cytoplasmic antibodies (ANCA) mainly in old men. This small vessel vasculitis is usually characterized by necrotizing granulomatous inflammation with multiorgan involvement. Kidneys could be involved as the main and life-threatening co...