Daptomycin pharmacokinetics were evaluated for burn patients. Burn patients had decreases in the maximum concentration of the drug in serum (44%) and the area under the concentration-time curve (47%) and increases in the volume of distribution (64%) and total clearance (77%) compared to healthy volunteers. In burn patients, daptomycin at 10 to 12 mg/kg of body weight/day would be required to ac...

BACKGROUND There is no established primary care solution for the rapidly increasing numbers of severely obese people with body mass index (BMI) > 40 kg/m(2). AIM This programme aimed to generate weight losses of ≥15 kg at 12 months, within routine primary care. DESIGN AND SETTING Feasibility study in primary care. METHOD Patients with a BMI ≥40 kg/m(2) commenced a micronutrient-replete 81...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309 5.9 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 294 5.6 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 290 5.5 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 316 6.0 20 to 24 years . . . . . . . . . . . . . . . . . . . . ....

1 Wittstein IS, Thiemann DR, Lima JAC, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 2005; 352: 539–48 2 Mori HH, Ishikawa SS, Kojima SS, et al. Increased responsiveness of left ventricular apical myocardium to adrenergic stimuli. Cardiovasc Res 1993; 27: 192–8 3 Tachotti Pires LJ, Cardoso Curiati MN, Vissoci Reiche F, et al. Stress-induced car...

There were 33 mongrel dogs weighing 17.7 to 22.2 kg (average, 17.5 kg) (39 to 49 Ib [average, 38.5 lb]) used as recipients. The experiment was completed in 11 animals. The other 22 died early of anesthetic, technical, and septic complications and are excluded from further discussion. In the 11 test dogs the donors (weight 9.5 to 20 kg [21 to 44 lb]) were smaller than their recipients, the avera...

To the Editor: In the American Heart Association’s (AHA) guidelines for the metabolic syndrome,1 the diagnosis of obesity is based on an abdominal circumference (AC) of 40 inches or more in males and 35 inches or more in females. For weight management, the AHA guidelines recommend reduction of weight to a body mass index (BMI) of less than 25 kg/m2. In this study, we compare that recommendation...

CONTEXT Adolescent obesity is becoming a national public health problem. Weight-loss medications including sibutramine facilitate weight control in adults and could be used with obese adolescents in combination with behavior therapy (BT). OBJECTIVE To examine whether increased weight loss in obese adolescents is induced when sibutramine is added to a family-based, behavioral weight control pr...

OBJECTIVE To determine how weight for gestational age affects urea and mineral excretion by preterm infants receiving total parenteral nutrition (TPN). STUDY DESIGN Daily urine samples were collected from all preterm infants given high calcium TPN, providing 30 kcal/g amino acids, during its first 44 months of use, and from all those given standard TPN, providing 25 kcal/g amino acids, over t...

Stavudine was administered (15 mg/kg of body weight) intravenously and orally to two monkeys in a randomized crossover study. Plasma and urine samples were analyzed for stavudine by high-performance liquid chromatography, and pharmacokinetic parameters were derived by a noncompartmental method. Total body clearance of stavudine was 0.64 liters/h/kg, with a steady-state volume of distribution of...

The purpose of this study was to measure the growth and body composition of pigs during normal or compensatory growth from 60 to 100 kg, without (cont) or with ractopamine (rac) supplementation (20 mg/kg of diet). Thirty-four pigs were scanned by dual X-ray absorptiometry (DXA) for body composition analysis at a starting weight of 61.4 ± 0.3 kg and at a final weight of 100.4 ± 0.5 kg. Half the ...