The effect of aqueous extract of Withania somnifera (L. Solanaceae) was studied against paclitaxel induced neutropenia in mice. After paclitaxel 1 mg/kg, i.v. administration significant fall in total WBC and absolute neutrophil count was observed on day 3 and day 5. W. Somnifera (200 mg/kg, p.o.) per se produced significant increase in neutrophil counts. W. somnifera (200 mg/kg, p.o.) when admi...

neutralization effects of acorus calamus and withania somnifera root extracts were tested against echis carinatus venom. both plant extracts were effectively neutralized the various pharmacological activities induced by echis carinatus venom. about 0.14 mg of acorus calamus and 0.16 mg of withania somnifera root extracts were able to completely neutralize the lethal activity of 2ld 50 of echis ...

Phytochemical and Pharmacological Profile of Withania somnifera Dunal: A ReviewQamar Uddin, L. Samiulla, V. K. Singh, S. Jamil

In Ayurveda, Withania somnifera is commonly known as Ashwagandha, its roots are specifically used in medicinal and clinical applications. It possesses numerous therapeutic actions which include anti-inflammatory, sedative, hypnotic and narcotic. Extracts from this plant have been reported for its anticancer properties. In this study we evaluated for the first time, the cytotoxic effect of Witha...

The present study deals with the diversity and distribution of VAMF at different sites with different selected plants. Maximum number of VAMF species were found at site IV (57 species) out of which Glomus species was most dominant (58%), followed by Acaulospora (19%), Scutellospora (8%), Sclerocystis (4.8%) and Gigaspora (1.6%) respectively. In site II 56 species of VAMF were observed with Glom...

Withania somnifera (L.) Dunal (Indian ginseng, winter cherry, Solanaceae) is widely used in traditional medicine. Roots are either chewed or used to prepare beverages (aqueous decocts). The major secondary metabolites of Withania somnifera are the withanolides, which are C-28-steroidal lactone triterpenoids. Withania somnifera extracts exert chemopreventive and anticancer activities in vitro an...

BACKGROUND Glycowithanolides (Withaferin A), is one of the main withanolides active principle isolated from plant Withania somnifera and is claimed that it possess the aphrodisiac, sedative, rejuvenate and life prolonging properties. OBJECTIVE In the present investigation, antioxidant activity of active principles of Withania somnifera was tested against D-galactose induced oxidative stress i...

objective: the main objective of the current study was to observe the ameliorative effect of withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology. materials and methods: in the present study, arsenic in the form of sodium arsenite was administered orally ...

Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently 'priming' has been suggested as a potential mechanism for enhancing cancer cell death. In this study we demonstrate that 'priming', in HT-29 colon cells, with W. somn...