The 26th Annual D. J. Davis Memorial Lecture on Medical History will be given at the University of Illinois College of Medicine, 817 South Wolcott Avenue, Room 106, on Wednesday, 5 March, 1969, at 1.00 p.m. The lecturer is Doctor Leo M. Zimmerman, Professor of Surgery and Professor and Chairman of the Department of the History and Philosophy of Medicine of the Chicago Medical School. The title ...

BACKGROUND Neonatal diabetes mellitus is a rare condition and it is important to differentiate it from other causes, such as hyperglycemia in infancy, for better outcomes. We report a case of an infant who presented to our neonatal intensive care unit in ketoacidosis and a comatose state. CASE REPORT Our case was an infant who presented to the neonatal intensive care unit at 38 days of age in k...

A rearrangement of genera and subgenera in the water mite family Mideopsidae is proposed, resulting in the following changes: Mideopsellinae Lundblad, 1937 and Phreatomideopsinae Schwoerbel, 1986 are synonymized with Mideopsidae Koenike, 1910; Djeboa K. Viets, 1911, Mideopsides Lundblad, 1943, Neoxystonotus Lundblad, 1927, Octomideopsis K. Viets, 1931 and Xystonotus Wolcott, 1900 are redefined ...

Micro-organisms produce significant barriers to the healing of chronic wounds (Kim et al, 2010). They are present in all wounds, although not all wounds become chronic. Microbes grow in both a planktonic phenotype (free-floating mobile single cells) and biofilm phenotype (a fixed polymicrobial community; James et al, 2008). A self-secreted matrix protects the biofilm from attack by the host imm...

Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disorder due to mutations in the EIF2AK3 gene. It is characterized by permanent neonatal diabetes mellitus, skeletal dysplasia, liver impairment, neutropenia and renal dysfunction. Liver is the most commonly affected organ and liver failure is the commonest cause of death in this syndrome. The EIF2AK3 gene encodes a transmembrane pro...

We report the first detailed examination of the brain of a patient with Wolcott-Rallison syndrome. Wolcott-Rallison syndrome is an extremely rare clinical manifestation of a lack of protein kinase R-like endoplasmic reticulum kinase (PERK) function caused by mutations in the PERK gene EIF2AK3. Protein kinase R-like endoplasmic reticulum kinase is thought to play a significant pathogenetic role ...