conclusions this study indicated that the optimization of gene transfer increases the expression of igf-1. high concentrations of igf-1, in combination with cell therapy, have a significant effect on wound healing. results in vitro, the maximum expression of igf1 (96.95 pg/ml) in transfected fibroblast cells was 24 hours after gene transfer. in vivo, it was clear that igf-1 gene therapy caused ...

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine that activates granulocyte and macrophage cell lineages. It is also known to have an important function in wound healing. This study investigated the effect of GM-CSF in wound healing of human corneal epithelial cells (HCECs). We used human GM-CSF derived from rice cells (rice cell-derived recombinant human GM-C...

Introduction: Traditionally Prangos ferulacea root is being used as an effective wound healing agent especially for pus-filled wounds both in human and stocks in the western north of Iran. Regarding the subject we decided to study P. ferulacea roots essential oil (PFE) for its antimicrobial and wound healing activities. Methods: The in vitro wound healing activity of PFE was evaluated in the mo...

K e y w o r d s F i s h e r ' s equation, Human peritoneal mesothelial cells, Invasion waves. I N T R O D U C T I O N Severa l a u t h o r s have p r o p o s e d t h a t c o n s t a n t profile, c o n s t a n t speed t r ave l l i ng waves p lay an i m p o r t a n t role in a n u m b e r of m ed i ca l app l ica t ions . For example , in e p i d e r m a l w o u n d heal ing , mode l s h a v e b...

Human thymosin beta 4 (TB4) is a small acidic peptide involved in angiogenesis, wound healing, cancer metastasis and cardiac repair. Currently human TB4 is synthesized chemically for research and this is costly. In order to obtain sufficient biologically active human TB4 economically, we cloned and overexpressed this protein in an Escherichia coli system. We also developed a one-step affinity p...

Objective(s): Chemokines are wound mediators that promote angiogenesis during wound healing. We hypothesized that Simvastatin in combination with the bone marrow mesenchymal stromal cells (BMSCs) improve burn wound healing by ameliorating angiogenesis via SDF-1α/CXCR4 pathway.Materials and Methods: Under general anesthesia, deep partial-...

background persian oak (quercus brantii) belongs to the fagaceae family. it is a medicinal plant which is commonly used by the tribes in south western iran to treat inflammatory and gastric ulcers. objectives the aim of this study was to evaluate the effectiveness of persian oak ointment on dermal wound healing in rats. materials and methods for making full-thickness wounds in rats, the excisio...

Achillea eriophora D.C. (Asteraceae), an endemic species in Iran, is used extensively in Iranian folk medicine to treat various ailments, including gastrointestinal disorders, skin inflammations and wound healing. The present study was aimed to investigate the effects of the methanolic extract of  A. eriophora leaves on the stimulation of human fibroblast cell proliferation and migration as two ...

Objective-The aim of this study was to investigate the healing effects of Ag+- zeolite/gelatin nanocomposite on excisional wound healing in rat animal model. Design-Experimental study Animals-Eighteen male Sprague-Dawly rats weighing 200-220g Procedure- Ag+- zeolite/gelatin nanocomposite was fabricated by sol-...

conclusions the designed safe irrigator syringe seems to be applicable in wound irrigation and superior to the conventional devices regarding efficacy and user comfort. results all of the interns stated that the new device is quite applicable for wound washing and is easy to handle. nine interns believed that safe irrigator syringe is superior to the conventional devices regarding efficacy and ...