The mitochondrial cloud is a unique cell structure found in stage I Xenopus oocytes that plays a role in mitochondriogenesis and in the distribution of germ plasm to the vegetal pole. Xcat-2 RNA specifically localizes to the mitochondrial cloud and moves with it to the vegetal subcortex in stage II oocytes. Later, in the 4-cell embryo, it is found in a pattern identical to the germ plasm. Follo...

We explore the use of the recently proposed 'total nuclear variation' (TVN) as a regularizer for reconstructing multi-channel, spectral CT images. This convex penalty is a natural extension of the total variation (TV) to vector-valued images and has the advantage of encouraging common edge locations and a shared gradient direction among image channels. We show how it can be incorporated into a ...

Dense motion estimation in X-ray fluoroscopy is challenging due to low soft-tissue contrast and the transparent projection of 3-D information to 2-D. Motion layers have been introduced as an intermediate representation, but so far failed to generate plausible motions because their estimation is ill-posed. To attain plausible motions, we include prior information for each motion layer in the for...

Patient-specific image-based dosimetry is considered to be a useful tool to limit toxicity associated with peptide receptor radionuclide therapy (PRRT). To facilitate the establishment and reliability of absorbed-dose response relationships, it is essential to assess the accuracy of dosimetry in clinically realistic scenarios. To this end, we developed pharmacokinetic digital phantoms correspon...

BACKGROUND Since tumors located in thorax region of body mainly move due to respiration, in the modern radiotherapy, there have been many attempts such as; external markers, strain gage and spirometer represent for monitoring patients' breathing signal. With the advent of fluoroscopy technique, indirect methods were proposed as an alternative approach to extract patients' breathing signals. M...

Two algorithms for solving misalignment issues in penalized PET/CT reconstruction using anatomical priors are proposed. Both approaches based on a recently published joint motion estimation and image method. The first approach deforms the to align it with functional one while second both images them measured data. Our current implementation alternates between alignment reconstruction. We have c...

CT scan by use of a beam-filter placed between the x-ray source and patient allows single-scan low-dose dual-energy imaging with minimal hardware modification to existing systems. We have earlier demonstrated feasibility such method multi-slit reciprocating along direction perpendicular rotation axis in cone-beam system. However, would face mechanical challenges when is supposed cooperate fast-...

background: since tumors located in thorax region of body mainly move due to respiration, in the modern radiotherapy, there have been many attempts such as; external markers, strain gage and spirometer represent for monitoring patients’ breathing signal. with the advent of fluoroscopy technique, indirect methods were proposed as an alternative approach to extract patients’ breathing signals. ma...

Introduction: The purpose of this study was to develop a technique for automatic segmentation based on Fourier descriptors for separating smooth objects from the background in SPECT-images. The aim of the segmentation method was to be able to automatically outline kidneys in SPECT-images of patients undergoing radionuclide therapy with 177 Lu-DOTATATE. The potential advantage of combining SPECT...