It has long been recognized since the early studies in Japan by Yamagiwa and Ichikawa with coal tar-induced carcinogenesis that exposure to environmental and dietary chemicals are likely to be responsible for the vast majority of human cancers. A large number of enzymes participate in both activation and inactivation pathways of carcinogen metabolism. These enzymes mainly function in xenobiotic...

Because of the evidence for the involvement of xenobiotic bioactivation in pulmonary toxicity and carcinogenesis, it is important to improve our understanding of the xenobiotic-metabolizing enzymes in isolated and cultured specific pulmonary cell populations. Some phase I and phase II xenobiotic-metabolizing enzyme activities, reduced glutathione (GSH), and gamma-glutamyl transferase (gamma-GT)...

untersucht. Die Häufigkeit der CYP1A1 Allele mit hoher Aktivität, CYP1A1*2A und Populationen. Abstract The basic principle of drug and xenobiotic metabolism in the body is to make them more water soluble and thus more readily excreted in the urine. Genetic polymorphisms of phases I and II xenobiotic transformation reactions are known to contribute considerably to interindividual variations in t...