BACKGROUND A standard treatment for unresectable advanced-stage intrahepatic cholangiocarcinoma (IHCC) has not yet been established. Although neoadjuvant concurrent chemoradiotherapy (CCRT) and liver transplantation are associated with long-term survival in select patients, the outcomes of CCRT for advanced-stage unresectable IHCC remain unclear. The aim of our study was to evaluate the outcome...

The Extreme Programming development Methodology (XP) seems appropriate for some teams or projects. Anecdotal stories from developers who have tried XP are often favorable. However, there is little empirical evidence to support or refute claims regarding XP. The Extreme Programming Evaluation Framework (XPEF) provides a benchmark measurement framework for researchers and practitioners to assess ...

Abstract. Aksomaitis and Burauskaite-Harju [Information Technology and Control, 38, 2009, 301-302] studied the distribution of max(X1, X2,..., Xp) when (X1, X2,..., Xp) follows the multivariate normal distribution. Here, we study the moments of min(X1, X2,..., Xp) and max(X1, X2,..., Xp) when (X1, X2,..., Xp) follows the most commonly known multivariate Pareto distribution. Multivariate Pareto ...

Escrow.com began implementation of XP as its development process in December 2000, in parallel with other significant organizational changes. This document describes the philosophical, logistical, physical and organizational changes that occurred both to enable XP implementation, and as a result of XP implementation. Implementation challenges as well as ongoing benefits of the XP process are di...

Xeroderma pigmentosum variant (XP-V) is a subtype of xeroderma pigmentosum (XP) disease with typical pigmentation and types of cancer in the oral maxillofacial and other sun-exposed regions. Few factors of tumor proneness in XP-V have been completely elucidated with the exception of the POLH [which encodes DNA polymerase η (pol η)] mutation. The aim of the present study was to identify the POLH...

Xeroderma pigmentosum (XP) is one of a number of autosomal recessive syndromes in humans characterized by a marked predisposition to cancer. Fibroblasts from these patients show a defect in DNA repair. The XP heterozygotes also show elevated skin cancer incidence, but reports concerning their DNA repair capacity are conflicting. In this study, the DNA repair capacity of four XP heterozygotes wa...

To assess the contribution to mutagenesis by human DNA repair defects, a UV-treated shuttle vector plasmili, p/.189, was passed through fibroblasts derived from Japanese \eroderma pigmentosum (XP) patients in two different DNA repair complementation groups (A and F). Patients with XP have clinical and cellular UV hypersensitivity, increased fre quency of skin cancer, and defects in DNA repair. ...

CS: Cockayne syndrome ERCC5: Excision Repair Cross-complementing Rodent Repair Deficiency Complementation Group 5 gene NER: Nucleotide excision repair UV: Ultraviolet WES: Whole exome sequencing XP: Xeroderma pigmentosum XP-G: Xeroderma pigmentosum complementation group G INTRODUCTION Xeroderma pigmentosum (XP) is an autosomal recessive genodermatosis caused by a germline loss of function in DN...

Xeroderma pigmentosum (XP) is one of a number of autosomal recessive syndromes in humans characterized by a marked predisposition to cancer. Fibroblasts from these pa tients show a defect in DMA repair. The XP hétérozygotes also show elevated skin cancer incidence, but reports concerning their DNA repair capacity are conflicting. In this study, the DNA repair capacity of four XP hétérozygot...