Soil sample from a site heavily contaminated with >10 wt.% zinc is sampled and extracted with aqueous solutions of ethylene diamine tetra-acetic cid (EDTA) that is a reagent frequently used to extract heavy metals in soil remediation. Three liquid/soil ratios (5/1, 20/1, and 100/1) were used n the extracting experiment. The molecular environment of the residual Zn in the EDTA-extract residues o...

To evaluate the influence of resveratrol on cellular zinc status, normal human prostate epithelial (NHPrE) cells were treated with resveratrol (0, 0.5, 1, 2.5, 5, and 10 microM) and zinc [0, 4, 16, and 32 microM, representing zinc-deficient (ZD), zinc-normal (ZN), zinc-adequate (ZA), and zinc-supplemented (ZS) conditions, respectively]. A progressive reduction in cell growth was observed in cel...

AIM To assess plasma zinc and copper concentration in individuals with autism and correlate these levels with symptom severity. SUBJECTS AND METHODS Plasma from 102 autistic individuals, and 18 neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Copper and zinc levels and Cu/Zn were analyzed for possible correlation with severity o...

Zinc plays a protective role in anti-atherosclerosis but the clear mechanism has not been proposed yet. In the present study, we evaluated whether zinc modulates atherosclerotic markers, VACM-1 and ICAM-1 and cell viability both in endothelial cells in vitro and mouse aortic cell viability ex vivo. In study 1, as in vitro model, endothelial EA.hy926 cells were treated with TNFalpha for 5 hours ...

The 1D polymeric Schiff base zinc complex, [LZn(2)Et(2)](n), where LH(2) = (NN'-ethylene-bis(4-iminopentan-2-one)) has been demonstrated as a useful synthetic metallo building block for the synthesis of homo and heteronuclear zinc cages. The reaction of [LZn(2)Et(2)](n) with CdI(2) afforded the hetero-nuclear cage, 1, [L(2)Zn(4)(Et)(2)CdI(4)], while reaction with HgI(2) afforded a hexanuclear z...

PURPOSE Zinc is an essential cofactor for normal cell function. Altered expression and function of zinc transporters may contribute to the pathogenesis of neurodegenerative disorders including macular degeneration. The expression and regulation of zinc transporters in the RPE and the toxicity of zinc to these cells were examined. METHODS Zinc transporters were identified in a human RPE cell l...

1, IO-Phenanthroline interacts with certain zinc metalloenzymes to form enzymatically inactive protein-zinc-phenanthroline complexes exhibiting ultraviolet absorption maxima analogous to those observed for zinc ions and phenanthroline in aqueous systems (1). Such spectral changes offer a means of studying directly the chemical mechanism of the enzymatic inhibition resulting from such interactio...

The electrodeposition of iron and Zn-Fe alloys on polycrystalline nickel was investigated in the 40.0-60.0 mol % zinc chloride1-ethyl-3-methylimidazolium chloride ionic liquid containing iron~II! at 90°C. Iron~II! was electrochemically reduced to iron metal before the reduction of zinc~II! to zinc metal, and anomalous codeposition of Zn-Fe did not occur in this ionic liquid. Underpotential depo...

In order to understand the insulinomimetic activity of zinc(II) complexes, we studied the metallokinetic features of zinc in the blood of normal rats given the zinc complexes, bis(maltolato)zinc(II) (Zn(mal)(2)) and bis(6-methylpicolinato)zinc(II) (Zn(6mpa)(2)) by comparing each of them with an ionic form of zinc chloride (ZnCl(2)). The bioavailability of the zinc(II) complexes following oral a...

The importance of zinc in biology is evidenced by the growing number of disease states that directly involve aberrant levels of zinc, including neurodegeneration, inflammation, diabetes, cancer and more. Zinc is a component of an estimated 10% of all proteins and has a well-established role in regulation of gene expression, primarily through activation of metalresponsive transcription factor-1 ...