In December 2012, the Food and Drug Administration (FDA) approved VariZIG, a varicella zoster immune globulin preparation (Cangene Corporation, Winnipeg, Canada) for use in the United States for postexposure prophylaxis of varicella for persons at high risk for severe disease who lack evidence of immunity to varicella* and for whom varicella vaccine is contraindicated. Previously available unde...

Pathogenesis Varicella and zoster are different clinical manifestations caused by the same (VZ) virus. Infection of a previously uninfected person produces varicella or in some cases an inapparent infection. Zoster is believed to result from the activation of VZ virus which has been present, but inactive, in the patient's dorsal root ganglion cells and/or his skin cells. Most are 'immune' to a ...

St. Mary’s Hospital, Division of Infectious Diseases, Waterbury, Connecticut, USA. Received for publication: August 13, 2011. Reprint request: Birinder S. Singh, M.D., St. Mary’s Hospital, Division of Infectious Diseases, Waterbury, Connecticut, USA. INTRODUCTION Varicella zoster virus (VZV) is a ubiquitous human virus that belongs to the subfamily alphaherpesvirinae.1 It contains the smallest ...

Studies of varicella-zoster virus gene expression during latency require the acquisition of human ganglia at autopsy. Concerns have been raised that the virus might reactivate immediately after death. Because features of varicella-zoster virus latency are similar in primate and human ganglia, we examined virus gene expression in tissues either processed immediately or kept at 4°C for 30 h befor...

Varicella-zoster virus (VZV) is a member of the Herpesviridae family, which causes varicella (chicken pox) and herpes zoster (shingles) in humans. Here, we report the complete genome sequence of varicella-zoster virus, isolated from a vesicular fluid sample, revealing the circulation of VZV clade VIII in Mexico.

The varicella-zoster virus (VZV) is a virus of the subfamily of Alfavirus responsible for infections with different clinical presentations. Primary infection occurs more frequently in the pediatric age presented as chickenpox. The reactivation of the infection occurs mainly in immunosuppressed patients, in the form of Herpes-Zoster [1]. Varicella-Zoster virus is associated with severe neurologi...

Using polymerase chain reaction, we detected the varicella-zoster virus genome in the vitreous humor of two patients with clinically diagnosed acute retinal necrosis. One of the two cases was thought to be caused by infection with a varicella-zoster virus lacking a PstI cleavage site. We could not find any clinical differences between the two substrains. The presence of a PstI cleavage site on ...

Varicella zoster virus (VZV) is human neurotropic virus. It becomes latent in dorsal root ganglia; it may reactivate and can cause dermatological manifestations; most common herpes zoster. Several neurological disorders occur such as encephalitis, meningitis, myelitis neuropathy. Longitudinally extensive transverse infrequent.The association of AQP4 antibody with has been documented few case re...

1. Chandra PC, Patel H, Schiavello HJ, Briggs SL. Successful pregnancy outcome after complicated varicella pneumonia. Obstet Gynecol 1998;92:680-682. 2. Dahl H, Marcoccia J, Linde A. Antigen detection: the method of choice in comparison with virus isolation and serology for laboratory diagnosis of herpes zoster in human immunodeficiency virus-infected patients. J Clin Microbiol 1997;35:347-349....

The anticomplement immunofluorescence (ACIF) test was compared with the fluorescent antibody-to-membrane antigen (FAMA) test for determining varicella-zoster virus antibody levels as a measure of varicella-zoster virus immunity status. The ACIF test was found to be comparable to the FAMA test in sensitivity and could be used for examining sera at low dilutions of 1:2 and 1:4. In addition, the A...