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Three samples of carcinoembryonic antigens were purified from liver métastasesof primary colon cancer. The asparagine-linked sugar chains of carcinoembryonic antigens (CEA) were released as oligosaccharides by hydrazinolysis and the structures of oligosaccharides, thus obtained, was studied in combination with methylation analysis and several limited exoglycosidase digestions. All three CEAs c...

The aggregation of the â-peptide into amyloid is a key pathological event in Alzheimer’s disease. This process (â-amyloidosis) involves the conversion of soluble random coil, R-helical or â-sheet conformations into insoluble, aggregated â-pleated sheet structures. The pH is a significant extrinsic factor that influences â-amyloidosis, which must be related to the presence of ionizable groups in...

Thirteen patients with metastatic breast carcinoma were given injec dons of 50—1593@ag of †̃311-monoclonal antibody (MAb) B6.2 immuno globulin G and F(ab')@for pharmacokinetic evaluation and radioimmu noimaging. Blood clearance of the †̃31I-MAb-B6.2 was biphasic. The mean half-times (t@, t@.,)for the immunoglobulin G were 33 ±1.7 and 20.9 ±11.0 h, respectively. The t@ for the F(ab'>@was 1...

Overexpression of the epithelial specific matrix metalloproteinase inatrilysin (MAT) has been correlated with enhanced tumorigenicity and tumor cell invasion using in vitro model systems. We have determined the effects of MAT expression on the development of mammary tumorigenesis using transgenic mice that express human MAT under the control of the mouse mammary tumor virus (MMTV)-long terminal...

We suggest and investigate a scheme for non-deterministic noiseless linear amplification of coherent states using successive photon addition, (â(†))(2), where â(†) is the photon creation operator. We compare it with a previous proposal using the photon addition-then-subtraction, ââ(†), where â is the photon annihilation operator, that works as an appropriate amplifier only for weak light fields...

Amitriptyline and Perphenazine in depressive ill ness: a controlled trial. I. Haider . . . . 195 Amnesic syndrome, the Grunthal-Störrmg case of.0. L. Zangwill .. .. .. .. i13 701 —¿ ————,—(C) .. .. .. .. 557 Amylobarbitone, cross-over study with Trimi 701 pramine. J. W. Hunter et a!. . . . . . . 667 —¿ sodium, controlled comparison with nitraze 383 pam (†̃Mogadon'). C. Davies an...

To determine the type of mutation induced by 8-hydroxyguanine in a mammalian system, we examined the mutations induced by a synthetic i -I la-ruv protooncogene containing 8-hydroxyguanine in the second po sition of codon 12 (GGC) in NIH3T3 cells. Transaction of this gene significantly increased the number of transformed foci. The c-Ha-r<w gene present in these foci was analyzed by the polymeras...

Cholecystokinin (CCK) is a growth factor for normal pancreas. Nu merous studies also suggest that CCK promotes pancreatic carcinogenesis in the rat. Our previous studies suggested that growth of preneoplastic pancreatic foci was stimulated by CCK more than that of normal pan creas. We hypothesized that such differential growth might be due to increased numbers of CCK receptors in neoplastic tis...

          The aim of this paper is to simulate the effects of some macroeconomic policy tools on production and inflation of Iran by the current worldwide financial and real crisis. The theoretical framework of the analysis is based on the so-called ‘IMF/World Bank Integrated Model’ which is the synthesis (a merger) of the basic monetary approach of the Balance of Payments used at t...