We discuss the recent derivation of the three-loop O(αα s) contribution to the Higgs boson production cross section via gluon fusion arising from diagrams with light quarks, using an effective theory approach. We show results for the updated prediction of this process accounting for all the new theoretical calculations and the newest MSTW PDFs.

Heavy quark production in γγ collisions is analyzed within the approach to hard collisions of photons recently proposed by the author. In this approach evaluating the cross section σ(γγ → QQ) in the “next–to–leading order of QCD” requires the inclusion of direct photon contributions up to the order αα s, whereas in the standard approach direct photon terms only up to the order ααs are taken int...

BACKGROUND Platelet-derived growth factors (PDGF)-AA and -CC mediate renal fibroblast proliferation and/or renal fibrosis. Whereas PDGF-CC binds to both the PDGF receptors (PDGFRs)-αα- and -αβ, PDGF-AA binds more selectively to the αα-receptor, suggesting potential differences in the biological activities. METHODS We compared signal transduction, gene expression as well as changes in the prot...

The early identification of some clinically significant hemoglobinopathies and precise differentiation of hemoglobin variants are important to provide early comprehensive medical care to prevent some serious complications, assess prognosis and offer genetic counseling. A prospective study of 500 infants from South Western Maharashtra showed that 0.4% (4 in 1000) of them had detectable levels of...

INTRODUCTION Haemoglobin Bart's (Hb Bart's) level is associated with α-thalassaemia traits in neonates, enabling early diagnosis of α-thalassaemia. The study aimed to detect and quantify the Hb Bart's using Cord Blood (CB) and CE Neonat Fast Hb (NF) progammes on fresh and dried blood spot (DBS) specimen respectively by capillary electrophoresis (CE). METHODS Capillarys Hemoglobin (E) Kit (for...

Human hemoglobin (Hb) and haptoglobin (Hp) exhibit an extremely high affinity for each other, and the dissociation of Hb tetramers into dimers is generally believed to be a prerequisite for complex formation. We have investigated Hp interactions with native Hb, αα, and ββ cross-linked Hb (ααXLHb and ββXLHb, respectively), and rapid kinetics of Hb ligand binding as well as the redox reactivity i...

Hemoglobin H (HbH) disease is the severe nonfatal form of α-thalassemia syndrome. It is usually caused by molecular defects of 3 of 4 α-globin genes (--/-α) which cause α-globin expression to be decreased. HbH disease is rare in Japan. Here, we report on a 6-year-old girl with HbH disease who had profound hypochromatic and microcytic anemia. Analysis of the α-globin genes of the patient's famil...

We discuss a simple method to evaluate the QCD corrections to ∆ρ. It assumes that the perturbative expansion in terms of MS parameters is meaningful and, unlike other studies, exploits significant available information concerning O(ˆ α 2 s) corrections. This approach leads to an enhancement of ∼ 26% relative to the conventional evaluation. QCD corrections to the Z 0 → b ¯ b amplitude are also c...

In this paper, we are concerned with the situations, where sometimes value two is reported erroneously as one in relation to size biased generalized negative binomial distribution (SBGNBD) with probability αα. We have obtained the Maximum likelihood estimator and Bayes estimator under general entropy loss function. A simulated study is carried out to access the performance of the maximum likeli...