نتایج جستجو برای: α agonist
تعداد نتایج: 212440 فیلتر نتایج به سال:
Complement C5a is a potent inflammatory chemoattractant and might be beneficial therapeutic target for the induction of an effective anti-tumour response. agonist antagonist modulation have been demonstrated to either promote or inhibit tumour development in EMT6 murine mammary cancer cells both vitro vivo studies. For studies Alamar Blue cell viability assay was used determination, immunofluor...
Background: Heteromeric αβ glycine receptor β+/αinterfaces have never been unambiguously characterized. Results: This interface, compared with the α+/αinterface, is highly sensitive to agonist and experiences distinct conformational changes upon agonist binding. Conclusion: The β+/αinterface exhibits distinct properties. Significance: Our investigation directs the β+/αinterface-specific drug de...
Nitric oxide (NO) is one of the most important immune molecules in innate immunity of invertebrates, and it can be regulated by norepinephrine in ascidian haemocytes. In the present study, the mutual modulation and underlying mechanism between norepinephrine and NO were explored in haemocytes of the scallop Chlamys farreri. After lipopolysaccharide stimulation, NO production increased to a sign...
Recent studies have suggested possible adverse effects of thiazolidinediones on bone metabolism. However, the detailed mechanism by which the activity of PPAR affects bone formation has not been elucidated. Impaired osteoblastic function due to cytokines is critical for the progression of inflammatory bone diseases. In the present study, we investigated the cellular mechanism by which PPAR acti...
Right ventricular (RV) hypertrophy is characterized by cardiac fibrosis due to endothelial-mesenchymal transition (EndMT) and increased collagen production in pulmonary arterial hypertension (PAH) patients, but the mechanisms for restoring RV function are unclear. Prostanoid agonists are effective vasodilators for PAH treatment that bind selective prostanoid receptors to modulate vascular dilat...
Graft-vs-host disease (GVHD) is a devastating disorder that determines the prognosis of patients who receive a bone marrow transplant. GVHD is caused by donor cells responding to host disparate MHC alleles. In this report, we demonstrate that ER-38925, a newly discovered retinoid agonist with selectivity to retinoic acid receptor subtype α (RAR-α), is a potent immunosuppressive agent in mouse m...
Abstract Background Fibrates activate peroxisome proliferator-activated receptor (PPAR)-α which is associated with lipid metabolism. Bezafibrate a non-selective PPAR-α agonist, whereas pemafibrate has been developed as higher selective agonist. Objective The efficacy and safety of for 24-week in patients dyslipidemia was examined comparison bezafibrate. Methods Sixty hypertriglyceridemia (fasti...
Chronic kidney disease (CKD) is characterised by specific lipoprotein abnormalities and insulin resistance. Dual activation of the peroxisome proliferators-activated receptors (PPAR) α and γ can significantly improve insulin sensitivity. The aim of the study was to investigate the effects of a dual PPAR α / γ agonist on lipoprotein abnormalities in patients with CKD. One mg of the dual PPAR α /...
Estrogen deprivation is considered responsible for many age-related processes, including poor wound healing. Guided by previous observations that estradiol accelerates re‑epithelialization through estrogen receptor (ER)‑β, in the present study, we examined whether selective ER agonists [4,4',4''-(4-propyl [1H] pyrazole-1,3,5-triyl)‑trisphenol (PPT), ER‑α agonist; 2,3-bis(4-hydroxyphenyl)-propio...
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