نتایج جستجو برای: β1
تعداد نتایج: 13587 فیلتر نتایج به سال:
Background: The production of recombinant proteins in Escherichia coli is one of the most valuable achievements in biotechnology, with many therapeutic and diagnostic applications; however, the aggregation and misfolding of proteins that result in the formation of insoluble inclusion bodies is a disruptive factor in this process. Various solubilization and refolding methods can be used to impro...
Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...
BACKGROUND The aim of the present study was to investigate the role of microRNA (miRNA) let-7a in down-regulation of β1-adrenoceptors (β1-AR) and elucidate the underlying mechanism of chronic ischemia heart failure (CIHF) in rats. METHODS AND RESULTS CIHF model was established by occlusion of coronary artery for 4 weeks. β1-AR level was obviously down-regulated and let-7a up-regulated in the ...
The transforming growth factor β1 (TGF-β1) belongs to a family of structurally related polypeptide factors. TGF-beta plays an important role in the pathobiology of invasion of malignant gliomas. The objective of the present study was to investigate the impact of TNF-α converting enzyme (TACE/ADAM17) signaling on the process of TGF-β1-stimulated migration and invasion of T98G glioma cells. We fo...
سابقه و هدف: tgf-β1 یکی از فاکتورهای رشد است که در کنترل عملکرد سلولی در هر دو حالت سلامت و بیماری نقش دارد. اما چگونگی اثر سیگار بر سطح و غلظت این سایتوکاین در مایع شیار لثه ای، همچنان ناشناخته باقی مانده است. هدف از این مطالعه بررسی رابطه مصرف سیگار با غلظت tgf-β1 موجود در مایع شیار لثه ای در بیماران مبتلا به پریودنتیت مزمن متوسط تا شدید بود. مواد و روشها: در مطالعه تحلیلی و مورد-شاهدی حاض...
BACKGROUND The role of transforming growth factor β1 (TGF-β1) and tumor necrosis factor α (TNF-α) in asthma is unclear. The aim of this study was to assess the relationships among polymorphisms, clinical phenotypes, and the serum levels of TGF-β1 and TNF-α. METHODS Polymorphisms of promoter of TGF-β1 (C-509T locus) and TNF-α (G-308 A locus; rs 1800629) in 217 asthmatic patients and 110 health...
Elevated levels of transforming growth factor-β1 (TGF-β1) and its positive correlation with Foxp3 expression in hepatitis E patients have indicated involvement of TGF-β1 in hepatitis E pathogenesis. The current study determined polymorphisms in TGF-β1 gene, plasma TGF-β1 levels and T effector (Teff) cell proliferation and explored their association in a case control study. Polymorphisms in thre...
زمینه و هدف: گاز خردل به عنوان گاز تاول زا موجب آسیب های متنوعی در اعضای مختلف بدن از جمله پوست می شود که موجب تغییر در اجزای سلولی از جمله dna و تظاهرات بالینی شایع از جمله خارش مزمن می گردد. ملکول tgf-β1 به عنوان یک سیتوکین با اعمال متنوع از جمله مهار رشد سلولی و تعدیل و سرکوب التهاب نقش مهمی در پروسه التهاب پوستی ایفا می کند به طوری که نقش ضد التهابی این ملکول و گیرنده های آن در التهاب پوستی...
Liver fibrosis is characterized by changes in tissue architecture and extracellular matrix composition. Liver fibrosis affects not only hepatocytes but also the non-parenchymal cells such as hepatic stellate cells (HSCs), which are essential for maintaining an intact liver structure and function. Transforming growth factor β1 (TGF-β1) is a multifunctional cytokine that induces liver fibrosis th...
To study the effects of transforming growth factor beta 1 (TGF-β1) on fibrosis and failure of regeneration of skeletal muscles, we generated a tet-repressible muscle-specific TGF-β1 transgenic mouse in which expression of TGF-β1 is controlled by oral doxycycline. The mice developed muscle weakness and atrophy after TGF-β1 over-expression. We defined the group of mice that showed phenotype withi...
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