α-tocopherol is a vitamin E isoform with potent antioxidant activity, while the γ-tocopherol of exerts more pro-inflammatory effects. In maternal–fetal environments, increased plasma concentrations are associated positive birth outcomes, higher linked negative pregnancy outcomes. However, little known about tocopherol in placental tissue and their role modulating oxidative stress, process that ...

Asthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Clinical studies suggest a number of protective dietary factors for asthma, including vitamin E. However, studies of vitamin E in allergy commonly result in seemingly conflicting outcomes. Recent work indicates that allergic inflammation is inhibited by supplementation with the puri...

The phytosterol and tocopherol contents of almond kernel oil were evaluated in three cultivars, including the Spanish cultivar ‘Marcona’ French cultivars ‘Ferragnès’ ‘Ferraduel’, grown under two different agro-climatic conditions, Zaragoza (Spain) Meknès (Morocco). analysis variance showed significant effects genotype on content, Δ5-Avenasterol, Δ7-Campesterol, Stigmasterol isomers. location ef...

Oxidative endothelial dysfunction is a critical initiator of vascular disease. Vitamin E is an effective antioxidant but attempts to use it to treat vascular disorders have been disappointing. This study investigated whether tocotrienols, the less abundant components of vitamin E compared to tocopherols, might be more effective at preserving endothelial function. Superoxide generated by hypoxan...

Members of the Apocynaceae plant family produce a large number of monoterpenoid indole alkaloids (MIAs) with different substitution patterns that are responsible for their various biological activities. A novel N-methyltransferase involved in the vindoline pathway in Catharanthus roseus showing distinct similarity to γ-tocopherol C-methyltransferases was used in a bioinformatic screen of transc...

  Background: The dried fruits of Silybum marianum (L.) Gaertn (Compositae) contain silymarin, an isomeric mixture of flavonolignans. Silymarin acts as a strong anti -hepatotoxic. This fruits contains a high amount of oil .  Objective: The objective of this study was to determine total lipid content, fatty acid composition and content of different kind of tocopherols in seed oils of S. marianum...

Knee osteoarthritis (OA) is a degenerative joint condition and a leading cause of physical disability in the United States. Quadriceps weakness and inflammatory cytokines contribute to the pathogenesis of knee OA, and both of which, increase with vitamin D deficiency. Other micronutrients, such as vitamins C and E and β-carotene, modulate inflammatory cytokines and decrease during inflammation....

Objective. To investigate vascular endothelial function (VEF) responses to a single low-density lipoprotein (LDL) apheresis session in hypercholesterolemic patients undergoing chronic treatment. Methods. We measured brachial artery flow-mediated dilation (FMD), plasma lipids, vitamin E (α- and γ-tocopherol), markers of oxidative/nitrative stress (malondialdehyde (MDA) and nitro-γ-tocopherol (NG...