While studying transgenic mice that overexpress human wildtype alpha-synuclein (Thy1-ASO, ASO) for typical brain alpha-synucleinopathy and central nervous system neuropathology, we observed progressive functional changes in the gastrointestinal and other peripheral organs. A more systematic study revealed that the gastrointestinal tract in ASO mice showed severe distension and blockage of the l...

PURPOSE A low ratio of serum eicosapentaenoic acid to arachidonic acid (EPA/AA) has been associated with coronary artery disease. We retrospectively examined serum concentrations of polyunsaturated fatty acids in patients with arteriosclerosis obliterans (ASO) and in non-atherosclerotic patients. METHODS From April 2011 to March 2012, serum EPA/AA was retrospectively examined in 33 consecutiv...

Approaches that improve upon the pharmacokinetic and pharmacodynamic properties of singlestrand antisense oligonucleotides are an active research topic. Antisense oligonucleotide phosphorothioates (ASOs) are highly protein bound. Therefore, it is likely that they traffic into and through cells via a protein to protein shuttling mechanism driven by binding affinity gradients.1 The ASO binding ev...

The choroid plexus (CP) is present on the ventricular walls of the brain, produces cerebrospinal fluid (CSF), contains many blood vessels, and is a major functional component of the blood-CSF barrier. The CP is an important site in the pathophysiology of various neurological diseases, including Alzheimer's disease and meningeal amyloidosis. We performed gene silencing in the CP in vivo by using...

[Purpose] The purpose of this study was to evaluate the kinematics of the ankle in the lunge to estabilish effectiveness of an ankle stretching orthosis (ASO) on the ankle dorsiflexion range of motion (ROM) of individuals with limited dorsiflexion ROM. [Subjects and Methods] Forty ankles with decreased dorsiflexion ROM of 20 participants were evaluated in this study. After wearing the ASO, part...

A prospective study was conducted to investigate the rate of group A streptococci (GAS) carriers and associated anti-streptolysin O (ASO) titers in serum samples in asymptomatic school children in spring in Duzce, Turkey. Pharyngeal swabs were obtained to detect the presence of GAS and blood samples were collected to determine elevated ASO titers in serum. A total of 351 asymptomatic primary sc...

It is known that food intake was associated with decreased risk of cancer, we prepared a compounded adlay seed oil (C-ASO) containing 0.5% cinnamaldehyde and 1% 6-gingerol and evaluated the preventive effects of the oral C-ASO on DMBA/TPA-induced skin carcinogenesis. In contrast to untreated carcinogenic mice, skin tumor incidence and multiplicity were decreased to some extent in single ASO-, c...

OBJECTIVE: To determine ASO titer profile by establishing ARF differential diagnoses of other diseases with high levels of ASO antibodies. METHODS: We investigated 78 patients with ARF at onset and follow-up, 22 with isolated chorea at onset, 45 with recurrent oropharyngeal tonsillitis, and 23 with recent flare of juvenile idiopathic arthritis. We tested ASO with automated particle-enhanced imm...

A 64-year-old woman with a history of a large-sized secundum atrial septal defect (ASD) underwent successful percutaneous closure with a 34-mm Amplatzer septal occluder (ASO) without apparent complications on April 25, 2002. Transthoracic echocardiography immediately following the closing procedure revealed that her ASO was well wedged, with no residual shunt or murmurs (Figure 1). At the third...