Poly(ethyleneoxide)-poly(propyleneoxide)-poly(ethyleneoxide) triblock copolymer (PEO-PPO-PEO) based plasmid delivery systems are increasingly drawing attention in the field of nonviral gene transfer because of their proven in vivo transfection capability. They result from the simple association of DNA molecules with uncharged polymers. We examined the physicochemical properties of PEO-PPO-PEO/D...

The objective of this work was to develop new coating materials based on poly(ethyleneoxide) (PEO), which was grafted onto polysilazane (PSZ) by hydrosilylation. Three types of PEO with different molecular weights (350, 750, 2000 g/mol) were studied. The kinetics and yields of this reaction have been surveyed by (1)H and (13)C NMR spectroscopy. The PEO grafting-density onto PSZ by hydrosilylati...

Submitted for the MAR13 Meeting of The American Physical Society Control ion transport by tuning the crystalline morphology in polyethylene oxide-based solid electrolyte SHAN CHENG, CHRISTOPHER LI, DERRICK SMITH, Drexel University — The crystalline structure of polyethylene oxide (PEO) strongly affects the ion transport in solid PEO-Lithium salt electrolytes. Four possible phases can exist in a...

The conformation of 36 kDa polyethylene oxide (PEO) dissolved in three glyme-Li(+) solvate ionic liquids (SILs) has been investigated by small angle neutron scattering (SANS) and rheology as a function of concentration and compared to a previously studied SIL. The solvent quality of a SIL for PEO can be tuned by changing the glyme length and anion type. Thermogravimetric analysis (TGA) reveals ...

Silica aerogels were prepared via the sol–gel process using tetramethoxysilane (TMOS) as the precursor and polyethylene oxide (PEO) of molecular weights 10,000 and 100,000 to provide a polymeric template for gelation. The experiments included eleven different formulations ranging from 100% 10,000MW PEO to 100% 100,000MW PEO in 10% increments. The total concentration of PEO was kept constant thr...

Measurements of DSC, NMR and high-frequency spectroscopy have been done on PEO-H2O and PEO-H2O-HQ mixed systems. DSC measurements show that water molecules contained in PEO are divided roughly into two species: freezable water and non-freezable water. By 1H-NMR measurements, PEO and H2O protons show an absorption peak around 3.6 ppm and 4.5 ppm, respectively. All the PEO-H2O samples containing ...

By use of a combined experimental and theoretical approach, a model poly(ethylene oxide) (PEO) brush system, prepared by spreading a poly(ethylene oxide)-poly(n-butyl acrylate) (PEO-PnBA) amphiphilic diblock copolymer onto an air-water interface, was investigated. The polymer segment density profiles of the PEO brush in the direction normal to the air-water interface under various grafting dens...

Nanoparticles formed from diblock copolymers of FDA approved PEO and PCL have generated considerable interest as in vivo drug delivery vehicles. Herein, we report the synthesis of the most extensive family PEO-b-PCL copolymers that vary over the largest range of number-average molecular weights (Mn: 3.6-57k), PEO weight fractions (fPEO: 0.08-0.33), and PEO chain lengths (0.75-5.8k) reported to ...

Medical grade Nano-polymers (NP) used to enhance circulation, drug and gene delivery. Injection of Polyethylene-oxide (PEO) increase tissue perfusion and decrease mean blood pressure in animal models. Polyethylene-oxide (PEO) NP’s ultra high molecular weight (2-5 x 10^6 Da) and rheological properties allow it to interact with endothelial cells to increase endothelial nitric oxide (eNO) and its ...