In the present study, the antinociceptive profiles of Agrimonia pilosa Ledeb extract were examined in ICR mice. Agrimonia pilosa Ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Agrimonia pilosa Ledeb extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cum...

BACKGROUND In Iranian traditional medicine, gum obtained from Astragalus gummifer and some other species of Astragalus was used as analgesic agent. OBJECTIVE In this study, we investigated the antinociceptive effect of several concentrations (125, 250, and 500 μg/kg body weight) of Astragalus gummifer gum (AGG) on thermal and acetic acid induced pain in mice. MATERIALS AND METHODS AGG was d...

BACKGROUND The combination of two analgesic agents offers advantages in pain treatment. Codeine and morphine analgesia is due to activation of opioid receptor subtypes. METHODS This study, performed in mice using isobolographic analysis, evaluated the type of interaction in intraperitoneal (ip) or intrathecal (it) coadministration of codeine and morphine, in three nociceptive behavioral model...

Purpose: To investigate potential analgesic and antioxidant properties in the ethanolic root extract of Clerodendrum viscosum Vent. Methods: Phytochemical analysis of the ethanolic root extract was evaluated using standard procedure. Analgesic activity test was carried out by acetic acid induced writhing in mice model. The antioxidant property of the plant extract was assessed by DPPH (1, 1-dip...

ETHNOPHARMACOLOGICAL RELEVANCE Leaf extracts of Buddleja globosa (Buddlejaceae) are used in Chilean folk medicine for wound healing. The anti-inflammatory (topic and per os), analgesic (per os) effects and the antioxidant activity of Buddleja globosa were for the first time reported by us. AIM OF THE STUDY Assess the antinociceptive activity of the methanol sequential and global extracts usin...

Secondary metabolites from plants are a good source for the NSAID drug development. We studied the analgesic activity of ethanolic extract of Erythrina variegata L. (Fabaceae) followed by molecular docking analysis. The analgesic activity of Erythrina variegata L. is evaluated by various methods viz., acetic acid-induced writhing test, hot plate and tail immersion test. Subsequently, molecular ...

This study was aimed to investigate analgesic and neuropharmacological actions of the methanolic extract of rhizomes of Hedychium coronarium. The analgesic activity was evaluated for its central and peripheral pharmacological actions using tail immersion method and acetic acid-induced writhing test in mice respectively. The extract, at the doses of 100, 200 and 400 mg/kg body weight, produced a...

foeniculum vulgare (fennel) has been widely used in traditional medicine for treatment of variousdiseases including pediatric colic. this study was designed to assess the antinociceptive effects of aqueousextract of f. vulgare on visceral pain and possible involvement of opioidergic, serotonergic, adrenergic andhistaminergic systems. the results of this study showed that aqueous extract of f. v...

calendula of.cinalis (asteraceae) is widely used in traditional medicine as an anti-in.ammatory agent and has also been reported to have anti-bacterial, anti-fungal and anti-viral activities.  sesquiterpene glycosides, saponins, triol, triterpenes and .avonoids are observed in its composition. the present study was designed to evaluate the antinociceptive effect of hydro-alcoholic extract of ca...

The crude methanolic extract of aerial parts of Euphorbia milli was tested for its antinociceptive property. The antinociceptive effect was evaluated usin chemical (acetic acid) induced pain paradigm. The acetic acid induced writhing was significantly attenuated by the crude methanolic extract. The mean number of writhing reduction of the crude methanolic extract was 12.34, 32.54 and 71.44 % at...