AIM To test the safety and effectiveness of hypertonic saline solution (HSS + F) as a strategy for weight loss and prevention of further deterioration of renal function. METHODS Patients admitted with acute decompensated heart failure (ADHF) who received HSS + F were included in the study. After a period of a standard ADHF treatment, our patients received an intravenous infusion of furosemide...

Homospermidine synthase (HSS), the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, is known to have its origin in the duplication of a gene encoding deoxyhypusine synthase. To study the processes that followed this gene duplication event and gave rise to HSS, we identified sequences encoding HSS and deoxyhypusine synthase from various species of the Convolvulaceae. We show...

Hierarchically semiseparable (HSS) matrix techniques are emerging in constructing superfast direct solvers for both dense and sparse linear systems. Here, we develop a set of novel parallel algorithms for key HSS operations that are used for solving large linear systems. These are parallel rank-revealing QR factorization, HSS constructions with hierarchical compression, ULV HSS factorization, a...

We present some superfast (O((m + n) log(m + n)) complexity) and stable structured direct solvers for m× n Toeplitz least squares problems. Based on the displacement equation, a Toeplitz matrix T is first transformed into a Cauchy-like matrix C, which can be shown to have small off-diagonal numerical ranks when the diagonal blocks are rectangular. We generalize standard hierarchically semisepar...

The mammalian beta-globin locus is a multigenic, developmentally regulated, tissue-specific locus from which gene expression is regulated by a distal regulatory region, the locus control region (LCR). The functional mechanism by which the beta-globin LCR stimulates transcription of the linked beta-like globin genes remains unknown. The LCR is composed of a series of 5 DNaseI hypersensitive site...

The human beta-globin locus control region (LCR) consists of four erythroid-specific DNaseI hypersensitive sites (HSs) at the 5' end of the beta-globin cluster. The LCR functions over a long distance on chromosome 11 to regulate transcription and replication of the beta-globin genes. To determine whether the HSs function independently or as an integrated unit, we analyzed the requirements for l...

Haishengsu (Hss) is a purified protein from Tegillarca granosa that has been used as a traditional Chinese medicine to treat cancer for more than a century. In this study, we observed the impact of Haishengsu (Hss) on the proliferation and differentiation of HL-60 cells in the leukemic cell line by taking tretinoin and AS2O3 as a positive control and making a comparative analysis between the ef...

Hierarchically semiseparable (HSS) matrix algorithms are emerging techniques in constructing the superfast direct solvers for both dense and sparse linear systems. Here, we develope a set of novel parallel algorithms for the key HSS operations that are used for solving large linear systems. These include the parallel rank-revealing QR factorization, the HSS constructions with hierarchical compr...

Hughes-Stovin Syndrome (HSS) is a very rare clinical disorder characterized by thrombophlebitis and multiple pulmonary and/or bronchial aneurysms. Less than 40 published cases of HSS have been described in English medical literature so far. The exact etiology and pathogenesis of HSS is unknown; possible causes include infections and angiodysplasia. HSS has also been considered as a variant of B...