Hepatocellular carcinoma (HCC) is a lethal malignancy with high mortality and poor prognosis. Oncogenic transcription factor Late SV40 Factor (LSF) plays an important role in promoting HCC. A small molecule inhibitor of LSF, Factor Quinolinone Inhibitor 1 (FQI1), significantly inhibited human HCC xenografts in nude mice without harming normal cells. Here we evaluated the efficacy of FQI1 and an...

The mouse ischemic hindlimb model is used widely for studying collateral artery growth (i.e., arteriogenesis) in response to increased shear stress. Nonetheless, precise measurements of regional shear stress changes along individual collateral arteries are lacking. Our goal is to develop and verify trans-illumination laser speckle flowmetry (LSF) for this purpose. Studies of defibrinated bovine...

Abstract The reaction of methane with oxygen from La 0.8 Sr 0.2 FeO 3-δ (LSF) and several LSF-Fe 2 O 3 configurations was studied in chemical looping mode. Shell core (Fe ) (four catalysts called CS-3, CS-4, CS-5 CS-6, over a range coverage), LSF mixed uniformly Fe (UM) (front) followed by (PIS) were packed tubular reactor. conducted at 900 °C weight hourly space velocity (g methane/g catalyst/...

Rapidly decoding the emotional content of a face is an important skill for successful social behavior. Several Event Related brain Potential (ERP) have indicated that emotional expressions already influence brain activity as early as 100 ms. Some studies hypothesized that this early brain response to fear depends on coarse-magnocellular inputs, which are primarily driven by Low Spatial Frequenc...

This paper presents a model-based method for coding the LSF parameters of LPC speech coders on a “long-term” basis, that is, beyond the usual 20–30 ms frame duration. The objective is to provide efficient LSF quantization for a speech coder with large delay but veryto ultra-low bit-rate (i.e., below 1 kb/s). To do this, speech is first segmented into voiced/unvoiced segments. A Discrete Cosine ...

The transcription factor LSF is highly expressed in hepatocellular carcinoma (HCC) and promotes oncogenesis. Factor quinolinone inhibitor 1 (FQI1), inhibits LSF DNA-binding activity and exerts anti-proliferative activity. Here, we show that LSF binds directly to the maintenance DNA (cytosine-5) methyltransferase 1 (DNMT1) and its accessory protein UHRF1 both in vivo and in vitro. Binding of LSF...

Composite electrodes were prepared by adding 40 wt % La0.8Sr0.2FeO3 (LSF) into porous yttria-stabilized zirconia (YSZ) and their performance was studied as a function of time and calcination temperature. X-ray diffraction (XRD) patterns of the LSF-YSZ composites indicated an expanded lattice parameter after calcination above 1523 K, suggesting that Zr reacted with the LSF to form a Zr-doped per...

We present a preliminary analysis of the line spread function (LSF) of the Cosmic Origins Spectrograph (COS) using FUV and NUV stellar spectra acquired during the SM4 Servicing Mission Observatory Verification (SMOV). Our results indicate that the on-orbit shape of the COS LSF with the HST optical telescope assembly (OTA) deviates from the profile measured in ground testing due to the appearanc...

L-sulforaphane (LSF) is a natural isothiocyanate found in cruciferous vegetables particularly broccoli. LSF has been identified as a potent antioxidant and anti-cancer agent and is widely known to regulate phase II detoxifying enzymes and induce cell cycle arrest or apoptosis in malignant cells in vitro and in vivo. Previous studies have found significant G2/M cell cycle arrest in response to L...

Lightweight steel-framed (LSF) construction, given its advantages, has the potential to reach high standards in energy and environmental performance of buildings, such as nearly zero-energy buildings (nZEB). When compared with traditional construction, LSF system offers distinct benefits in such fields as sustainability, cost-effectiveness, constructive process, and safety at work. Despite the ...