A system-on-chip (SOC) usually consists of many memory cores with different sizes and functionality, and they typically represent a significant portion of the SOC and therefore dominate its yield. Diagnostics for yield enhancement of the memory cores thus is a very important issue. In this paper we present two data compression techniques that can be used to speed up the transmission of diagnost...

BACKGROUND Previous studies of ion channel regulation by G proteins have focused on the larger, heterotrimeric GTPases, which are activated by heptahelical membrane receptors. In contrast, studies of the Rho family of smaller, monomeric, Ras-related GTPases, which are activated by cytoplasmic guanine nucleotide exchange factors, have focused on their role in cytoskeletal regulation. RESULTS H...

By Hongquan Xu∗ and Ching-Shui Cheng† University of California, Los Angeles, and University of California, Berkeley Chen and Cheng [Ann. Statist. 34 (2006) 546–558] discussed the method of doubling for constructing two-level fractional factorial designs. They showed that for 9N/32 ≤ n ≤ 5N/16, all minimum aberration designs with N runs and n factors are projections of the maximal design with 5N...

The coordination and binding of the Mg2+ ion in the nucleotide-binding site of p21 have been investigated using site-directed mutagenesis, kinetic methods, and phosphorous N M k Mg2+ in the p21*nucleotide.Mg2+ complex appears to be in fast equilibrium with the solvent. The dissociation constant between Mg2+ and the p21-GDP complex was determined to be 2.8 pM. It decreases 30or 16-fold on substi...

The CrkL adaptor protein is involved in signaling from the receptor for erythropoietin (Epo) as well as interleukin (IL)-3 and activates beta(1) integrin-mediated hematopoietic cell adhesion through its interaction with C3G, a guanine nucleotide exchange factor for Rap1. We demonstrate here that Epo as well as IL-3 activates Rap1 in an IL-3-dependent hematopoietic cell line, 32D, expressing the...

We have examined the role of ras-related rab proteins in transport from the ER to the Golgi complex in vivo using a vaccinia recombinant T7 RNA polymerase virus to express site-directed rab mutants. These mutations are within highly conserved domains involved in guanine nucleotide binding and hydrolysis found in ras and all members of the ras superfamily. Substitutions in the GTP-binding domain...

The point placement problem is to determine the positions of a set of n distinct points, P = {p1, p2, p3, . . . , pn}, on a line uniquely, up to translation and reflection, from the fewest possible distance queries between pairs of points. Each distance query corresponds to an edge in a graph, called point placement graph (ppg), whose vertex set is P . The uniqueness requirement of the placemen...

We are given a stack of pancakes of different sizes and the only allowed operation is to take several pancakes from top and flip them. The unburnt version requires the pancakes to be sorted by their sizes at the end, while in the burnt version they additionally need to be oriented burnt-side down. We present an algorithm with the average number of flips, needed to sort a stack of n burnt pancak...

We have used the chemotactic ability of Dictyostelium cells to examine the roles of Rho family members, known regulators of the assembly of F-actin, in cell movement. Wild-type cells polarize with a leading edge enriched in F-actin toward a chemoattractant. Overexpression of constitutively active Dictyostelium Rac1B(61L) or disruption of DdRacGAP1, which encodes a Dictyostelium Rac1 GAP, induce...