nloaded -302 is the major microRNA found in human embryonic stem cells and induced pluripotent stem cells, function has been unclear. In mice, there is evidence that miR-302 may silence p21Cip1 (CDKN1A) to te cell proliferation, whereas studies in human reprogrammed pluripotent stem cells suggested that ed miR-302 expression inhibited cell cycle transit. Here, we clarify this difference, report...

Brazil has rich biodiversity, harboring native plants with potential for medicinal use, including species of the Campomanesia genus. Although public policies to encourage phytotherapy advocate best use plant most listed in official forms and monographs are exotic species. Thus, aim this study is identify research trends involving main species, using scientometric tools, so that, by viewing know...

The microRNAs (miRNAs) are small, non-coding RNAs that modulate protein expression by interfering with target mRNA translation or stability. miRNAs play crucial roles in various functions such as cellular, developmental, and physiological processes. The spatial expression patterns of miRNAs are very essential for identifying their functions. The expressions of miR-302 and miR-367 are critical i...

http://www.sciencemag.org/cgi/content/full/302/5652/1960 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/302/5652/1960/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...

electric arc furnace dust (eafd) of ferromanganese production units, in the form of slurry, contains tar, alkalies, manganese, zinc, iron, silica, calcium, aluminum and other elements. a hydrometallurgical route based on solvent extraction technique was investigated for selective separation of manganese from the dust. leaching of the eafd resulted in an aqueous feed containing 4 g/l of manganes...

abstract in order to evaluate the effects of different depths of irrigation by sprinkler irrigation system on water use efficiency (wue) of new early maize cultivar ksc302, an experiments was carried out in karj during 2006 and 2007. experimental design was split plot based on randomized complete blocks with three replications. main plots were three irrigation levels: 75%, 100% and 125% etc (es...

Ethnographic revisits have become an increasing practice in the social sciences, designed to advance the understanding of history through the linking of micro processes and societal structures. In this article I revisit my study of Zambianisation on the Copperbelt, conducted between 1968 and 1972. The methodology of the extended case method is used first to re-present the original study and the...

* Correspondence: [email protected] Department of Biological Sciences, Hunter College and The Graduate Center Biochemistry and Biology Programs, CUNY, 695 Park Ave, New York, NY 10065, USA doi:10.1186/bcr3130 Cite this article as: Brekman A, et al.: Correction: A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation. Breast Cancer Rese...

Recently, we showed that hypoxia is a critical microenvironmental factor in multiple myeloma, and that the hypoxia-activated prodrug TH-302 selectively targets hypoxic multiple myeloma cells and improves multiple disease parameters in vivo. To explore approaches for sensitizing multiple myeloma cells to TH-302, we evaluated in this study the antitumor effect of TH-302 in combination with the cl...