According to Barsalou (1992) frames as recursive attribute-value structures form the general format of cognitive concepts. Based on empirical research, Barsalou’s focus in developing frame theory was not on providing a formal theory. Our project proposes to both sharpen and generalize his intuitive conceptions by developing an adequate formal model for frames. Our goal is to obtain a better und...

در این مقاله، به بررسی اثر پارامترهای گوناگون بر شکل تپ‌های گسیلی لیزر 2CO تپی پرداخته شده است. راستا، عوامل مختلفی مانند: فشار گاز و هم‌­چنین طول تشدیدگر تغییر داده شدند هر حالت به‌همراه اندازه انرژی آن‌ها ثبت گردیدند. نتایج نشان می‌­دهد که با افزایش گاز، به‌شدت می‌یابد، به‌گونه‌ای 2 برابر 3 شدن فشار، 5 برابر، پهنای زمانی تپ‌ها نیم یک‌سوم زمان برساخت آن‌­ها نیز 9/0 7/0 اندازه‌های اولیه‌ی خود م...

Structural coverage of the human kinome has been steadily increasing over time. The structures provide valuable insights into the molecular basis of kinase function and also provide a foundation for understanding the mechanisms of kinase inhibitors. There are a large number of kinase structures in the PDB for which the Asp and Phe of the DFG motif on the activation loop swap positions, resultin...

The ATP site of kinases displays remarkable conformational flexibility when accommodating chemically diverse small molecule inhibitors. The so-called activation segment, whose conformation controls catalytic activity and access to the substrate binding pocket, can undergo a large conformational change with the active state assuming a 'DFG-in' and an inactive state assuming a 'DFG-out' conformat...

The catalytic activity of many protein kinases is controlled by conformational changes of a conserved Asp-Phe-Gly (DFG) motif. We used an infrared probe to track the DFG motif of the mitotic kinase Aurora A (AurA) and found that allosteric activation by the spindle-associated protein Tpx2 involves an equilibrium shift toward the active DFG-in state. Förster resonance energy transfer experiments...

Two grant numbers are inadvertently omitted in the Funding section. The correct funding information is as follows: Authors are funded by the following grants from the DFG (http://www.dfg.de/en/) (DFG BO3790/1-1), DFG (FI1781/1-1) and the following grants from the ESRC (http://www.esrc.ac. uk/) (ES/L010690/1) and (ES/M009203/1). The funders had no role in study design, data collection and analys...

DFG, 410830482, Multi-Domain Modellierung und Optimierung eines integrierten Energieversorgungs- Fahrzeugsystems fur urbane Ballungsraume

We report optical parametric amplification (OPA) of low-frequency infrared pulses in the intermediate region between terahertz (THz) frequency and mid-infrared (MIR), i.e. , from 16.9 to 44.8 THz (6.7–17.8 ?m). The 255-fs laser output Yb:KGW regenerative amplifier is compressed 11-fs using a multi-plate broadening scheme, which generates THz-to-MIR with spectrum extending approximately 50 by in...

Modelling and simulation of complex processes in key technologies are the main issues of the DFG Research Center. Being able to efficiently deal with the complex models established and having the corresponding mathematical basis available, engineers and practitioners are interested in optimizing these models according to some objective. This is reflected by several scientific projects in the Ce...