High capacity Last Level Cache (LLC) architectures have been proposed to mitigate the widening processor-memory speed gap. These LLC architectures have been realized using DRAM or SpinTransfer-Torque Random Access Memory (STT-RAM) memory technologies. It has been shown that STT-RAM LLC provides improved energy efficiency compared to DRAM LLC. However, existing STT-RAM LLC suffers from increased...

Vascular endothelial growth factor (VEGF) plays a critical role in tumor progression, angiogenesis and metastasis. Cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)2, MMP9 and wild-type (WT) p53 has been found to regulate the production of VEGF. Whether VEGF regulates the production of COX-2, MMP2, MMP9 and WTp53, however, has yet to be determined. This study examined the influence of the ...

AIMS To microscopically analyze the chemotherapeutic response of tumors using in vivo staining based on an annexinV-Cy5.5 probe and independently asses their apoptotic count using quantitative histological analysis. METHODS Lewis Lung Carcinomas cells, that are sensitive (CS-LLC) and resistant (CR-LLC) to chemotherapy were implanted in nude mice and grown to tumours. Mice were treated with cy...

The role of P-glycoprotein (P-gp) in the basal-to-apical uptake and flux of L-3,4-dihydroxyphenylalanine (L-dopa) was studied in LLC-PK(1) and LLC-GA5 Col300 cells, a renal cell line expressing the human P-gp in the apical membrane. In the absence of verapamil, LLC-GA5 Col300 cells accumulate less calcein (0.5 microM) than do LLC-PK(1) cells. In LLC-PK(1) cells, pretreatment with verapamil (25 ...

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