The metabolism of valspodar (PSC 833; PSC), which is developed as a multidrug resistance-reversing agent, was investigated to assess the potential for drug-drug interactions and the pharmacological activity of major metabolites. The primary metabolites of PSC produced by human liver microsomes were monohydroxylated, as revealed by LC/MS. The major site of hydroxylation was at amino acid 9, resu...

A 62-kDa cell surface antigen (M9) of Mycoplasma gallisepticum PG31 that mediates antibody-induced agglutination of the organism was purified and subjected to N-terminal amino-acid sequencing. A 999-bp region of the cDNA encoding the M9 protein was generated by reverse transcription-PCR, and its nucleotide sequence was determined. PCR primers based on this sequence were used to screen a genomic...

Use of the highly sensitive Hokupa’a/Gemini curvature wavefront sensor has allowed for the first time direct adaptive optics (AO) guiding on M8-M9 very low mass (VLM) stars. An initial survey of 20 such objects (SpT=M8-M9) discovered 4 binaries. Three of the systems have separations of less than 4.2 AU and similar mass ratios (∆K < 0.8 mag; 0.85 < q < 1.0). One system, however, did have the lar...

CCD observations have been used to study sixteen of the previously known variables in the Oosterhoo type II globular cluster M9. The properties of the RR Lyrae variables in M9 are compared with those in the Oosterhoo type I cluster M3. Methods devised by Simon, Jurcsik and Kovv acs have been used to derive physical parameters for the stars from Fourier analysis. The mean metal abundance so deri...

Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...

Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...

antifungal and antibacterial activities at concentrations of 7.8 to 15,6uglml, respectively, and that a possible target of the ITC compounds might be the cellular sulfhydryl group, In recent years, a number of multidrug transporters have been found in various organisms including bacteria and human cells.3) A promising way to conquer such multidrug resistance is to inactivate the eMux protein in...