BACKGROUND The benefits of lung-protective ventilation (LPV) with a low tidal volume (6 mL/kg of ideal body weight [IBW]), limited plateau pressure (< 28-30 cm H2O), and appropriate positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome have become apparent and it is now widely adopted in intensive care units. Recently evidence for LPV in general anaesthesi...

BACKGROUND Data informing the use of boosted protease inhibitor (PI) monotherapy as second-line treatment are limited. There are also no randomized trials addressing treatment options after failing first-line non-nucleoside reverse transcriptase inhibitor (NNRTI)-regimens. METHODS HIV-infected subjects ≥18 years, with HIV RNA≥1,000 copies/ml while using NNRTI plus 2 NRTIs, and naive to PIs we...

The shortcomings of a popular LPV gain-scheduling design approach are demonstrated by a simple counterexample. It is shown that, for a very general class of nonlinear systems, such an ad hoc design approach is unnecessary since soundly-based methods exist for transforming the plant dynamics into LPV/quasi-LPV form.

BACKGROUND Analysis of potentially different impact of Lopinavir/Ritonavir (LPV/r) on non-B subtypes is confounded by dissimilarities in the conditions existing in different countries. We retrospectively compared its impact on populations infected with subtypes B and C in Israel, where patients infected with different subtypes receive the same treatment. METHODS Clinical and demographic data ...

The toxic potential of nevirapine in pregnant women with CD4 count over 250 cells mm and the unsatisfactory efficacy of nelfinavir in patients with baseline Viral Load (VL) over 100,000 copies mL has prompted the use of Lopinavir/ritonavir (LPV/r) in selected situations. This study aims to assess safety of LPV/r in pregnancy. Medical records from pregnant women receiving LPV/r were retrospectiv...

Lopinavir (LPV) is the preferred HIV protease inhibitor in pregnancy, but it is unknown if gestational diabetes mellitus (GDM) affects its disposition. Hepatic protein expression and plasma protein binding are altered in rodent models of GDM. Because LPV is influenced by hepatic transporters and metabolic enzymes and is highly protein bound, it was hypothesized that streptozotocin-induced GDM w...

This article presents parameter estimation of continuous-time polytopic models for a linear parameter varying (LPV) system. The prediction error method of linear time invariant (LTI) models is modi ed for polytopic models. The modi ed prediction error method is applied to an LPV aircraft system whose varying parameter is the ight velocity and model parameters are the stability and control deriv...

This study evaluates clinical, virological and immunological responses to antiretroviral (ARV) therapy based on Lopinavir/ritonovir (LPV/r) in previously protease -inhibitor-experienced children. The study included 29 Brazilian children (median age = 5.91 years) who had failed previous ARV therapy and had begun a regimen based on LPV/r. At 12 months follow-up, a good virological response to LPV...

Linear Parameter Varying (LPV) systems appear in a form of LTI state space representations where the elements of the A(ρ), B(ρ), C(ρ) matrices depend on an unknown but at any time instant measurable vector parameter ρ ∈ P. This paper describes a geometric view of LPV systems. Geometric concepts and tools of invariant subspaces and algorithms for LPV systems affine in the parameters will be pres...