Climate change-related catastrophic events have a considerable influence on south-western coastal agriculture in Bangladesh. The objectives of this study are to measure the agricultural vulnerability households Bangladesh due climate-induced disasters and find sub-indicators adaptive capacity (AC) that vulnerability. An index (AVI) was developed by using intergovernmental panel climate change (...

PURPOSE The overexpression of c-myc associated with uncontrolled cell proliferation is a frequent genetic event in androgen-refractory prostatic neoplasia. The purpose of this study was to evaluate the bioavailability and efficacy of a novel antisense phosphorodiamidate morpholino oligomer directed against c-myc, AVI-4126, in PC-3 androgen-independent human prostate cancer xenograft murine mode...

Expression of c-myc protein is associated with cell proliferation. The present study uses antisense oligomers to inhibit c-myc expression in the regenerating rat liver after 70% partial hepatectomy (PH). Antisense phosphorodiamidate morpholino oligomers (novel DNA analogs) were administered i.p. immediately after surgery to block expression of c-myc within the first 24 h after PH. A 20-mer PMO ...

Bitterness perception is known to be an important factor in individuals' dietary behaviors and is also associated with the sensing of nutritious/noxious molecules for subsequent metabolic responses in multiple organs. Therefore, the genetic variation in bitterness sensing may be associated with diet-related diseases, including colorectal cancer (CRC). We investigated the influence of variations...

BACKGROUND We report clinical safety and biochemical efficacy from a dose-ranging study of intravenously administered AVI-4658 phosphorodiamidate morpholino oligomer (PMO) in patients with Duchenne muscular dystrophy. METHOD We undertook an open-label, phase 2, dose-escalation study (0·5, 1·0, 2·0, 4·0, 10·0, and 20·0 mg/kg bodyweight) in ambulant patients with Duchenne muscular dystrophy age...

AIMS Optimization of the AV-interval (AVI) in DDD pacemakers improves cardiac hemodynamics and reduces pacemaker syndromes. Manual optimization is typically not performed in clinical routine. In the present study we analyze the prevalence of E/A wave fusion and A wave truncation under resting conditions in 160 patients with complete AV block (AVB) under the pre-programmed AVI. We manually optim...

More researchers started using real-time traffic surveillance data, collected from loop/radar detectors (LDs), for proactive crash risk assessment. However, there is a lack of prior studies that investigated the link between real-time traffic data and crash risk of reduced visibility related (VR) crashes. Two issues that have not explicitly been addressed in prior studies are; (1) the possibili...

With an archival data set from Australian-based asynchronous video interview (AVI) vendor, we examined how employers implemented AVI features as a step toward understanding AVIs can be more optimally designed. The multilevel contained information about 2,550,105 responses 627,999 candidates to 52,623 questions, nested within 12,105 templates. We found that were often used for small applicant po...

Objectives: The present study was performed to investigate the effect of voice problems on related quality life in elderly with, without disorders, according genders by using Aging Voice Index-Korean version (AVI-KR).Methods: AVI-KR, a translated original Index (AVI) into Korean and verified for reliability validity, implemented with 50 people disorders (normal group) 76 (patient group). Statis...