Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection with a high mortality. 5-Hydroxytryptamine (5-HT) is an important regulatory factor in inflammation. The aim of this study is to investigate the role of 5-HT on cecal ligation and puncture- (CLP-) induced sepsis in the mouse model. CLP was performed on C57B/6 wild-type (WT) mice and try...

Kidney injury, heart injury, and cytokine-induced vascular hyperpermeability are associated with high rates of morbidity and mortality in sepsis. Although the mechanism remains unknown, apolipoprotein A-I (apoA-I) mimetic peptide 4F reduces inflammation and protects HDL levels, which are reduced in sepsis. We hypothesized that 4F also protects kidneys and hearts in a rat model of cecal ligation...

BACKGROUND Immunonutrition in sepsis, including n-3 poly-unsaturated fatty acids (PUFAs) or L-arginine supplementation, is a controversial issue that has yielded a great number of studies for the last thirty-five years, and the conclusions regarding the quantity and quality of this support in patients are deceiving. The aim of the present experimental study is to investigate the effects of a pr...

Constraint logic programming is one of the most attractive research areas in logic programming. Due to [JL87] the theoretical foundation of a general constraint logic programming language scheme CLP(X ) is available. Unfortunately, implementing a CLP(X ) system for some domain X is a difficult task. The problematic points are providing a constraint solver and ensuring the incrementality of the ...

A widely used property of Prolog is that it is possible to write Prolog programs to construct and manipulate other Prolog programs in a very general manner. Unfortunately , this property is not carried over to richer languages such as CLP(R) { the manipulation of CLP(R) programs in CLP(R) is quite limited. The reason is that the equality of terms in CLP(R) is not based on their syntactic struct...

Objectives: In this study, we investigated the possible useful effectiveness of Sinapic acid on rat kidney and lung tissues in an experimental cecal ligation puncture (CLP) model. Methods: CLP model was created for rats group. 20 mg/kg given CLP-Sinapic At end experiment, were collected biochemical analyzes evaluated. Results: For tissue samples; antioxidant levels decreased, oxidant increased ...

Mice homozygous for the autosomal recessive mutation claw paw (clp) are characterized by limb posture abnormalities and congenital hypomyelination, with delayed onset of myelination of the peripheral nervous system but not the central nervous system. Although this combination of limb and peripheral nerve abnormalities in clp/clp mice might suggest a common neurogenic origin of the syndrome, it ...

Xu H, Garver H, Fernandes R, Galligan JJ, Fink GD. Altered L-type Ca channel activity contributes to exacerbated hypoperfusion and mortality in smooth muscle cell BK channel-deficient septic mice. Am J Physiol Regul Integr Comp Physiol 307: R138–R148, 2014. First published May 14, 2014; doi:10.1152/ajpregu.00117.2014.—We determined the contribution of vascular large conductance Ca -activated K ...

We propose a parametric introduction of intensionally defined sets into any CLP (D) language. The result is a language CLP ({D}), where constraints over sets of elements of D and over sets of sets of elements, and so on, can be expressed. The semantics of CLP ({D}) is based on the semantics of logic programs with aggregates and the semantics of CLP over sets. We investigate the problem of const...

We determined the contribution of vascular large conductance Ca2+-activated K+ (BK) and L-type Ca2+ channel dysregulation to exaggerated mortality in cecal ligation/puncture (CLP)-induced septic BK channel β1-subunit knockout (BK β1-KO, smooth muscle specific) mice. CLP-induced hemodynamic changes and mortality were assessed over 7 days in wild-type (WT) and BK β1-KO mice that were either untre...