BACKGROUND Connected individuals (or nodes) in a network are more likely to be similar than two randomly selected nodes due to homophily and/or network influence. Distinguishing between these two influences is an important goal in network analysis, and generalized estimating equation (GEE) analyses of longitudinal dyadic network data are an attractive approach. It is not known to what extent su...

BACKGROUND The celebrated generalized estimating equations (GEE) approach is often used in longitudinal data analysis While this method behaves robustly against misspecification of the working correlation structure, it has some limitations on efficacy of estimators, goodness-of-fit tests and model selection criteria The quadratic inference functions (QIF) is a new statistical methodology that o...

Correlated response data often arise in longitudinal and familial studies The marginal regression model and its associated generalized estimating equation GEE method are becoming more and more popular in handling such data Pepe and Anderson pointed out that there is an important yet implicit assumption behind the marginal model and GEE If the assumption is violated and a non diagonal working co...

As countries become increasingly urbanized, understanding how urban areas are changing within the landscape becomes increasingly important. Urbanized areas are often the strongest indicators of human interaction with the environment, and understanding how urban areas develop through remotely sensed data allows for more sustainable practices. The Google Earth Engine (GEE) leverages cloud computi...

Longitudinal data with binary repeated responses are now widespread among clinical studies and standard statistical analysis methods have become inadequate in the answering of clinical hypotheses. Instead of such conventional approaches, statisticians have started proposing better techniques, such as the Generalized Estimating Equations (GEE) approach and Generalized Linear Mixed Models (GLMM) ...

The anti-neoplastic prodrug, cyclophosphamide, requires biotransformation to phosphoramide mustard (PM), which partitions to volatile chloroethylaziridine (CEZ). PM and CEZ are ovotoxicants, however their ovarian biotransformation remains ill-defined. This study investigated PM and CEZ metabolism mechanisms through the utilization of cultured postnatal day 4 (PND4) Fisher 344 (F344) rat ovaries...

This project discusses the Generalized Estimating Equation (GEE) model and its application for longitudinal data. For many longitudinal studies involving a discrete (count or categorical) response variable, and for some studies involving a continuous response variable, it is difficult to justify a fully parametric model for the data. In these circumstances, the method of GEE provides consistent...