BACKGROUND Throughout evolution, the LIM domain has been deployed in many different domain configurations, which has led to the formation of a large and distinct group of proteins. LIM proteins are involved in relaying stimuli received at the cell surface to the nucleus in order to regulate cell structure, motility, and division. Despite their fundamental roles in cellular processes and human d...

The LIM domain is a zinc finger structure that is present in several types of proteins, including homeodomain transcription factors, kinases and proteins that consist of several LIM domains. Proteins containing LIM domains have been discovered to play important roles in a variety of fundamental biological processes including cytoskeleton organization, cell lineage specification and organ develo...

An infinitary version of the notion of free products has been introduced and investigated by G. Higman [5]. Let Gi(i ∈ I) be groups and ∗i∈XGi the free product of Gi(i ∈ X) for X ⋐ I and pXY : ∗i∈YGi → ∗i∈XGi the canonical homomorphism for X ⊆ Y ⋐ I. ( X ⋐ I denotes that X is a finite subset of I.) Then, the unrestricted free product is the inverse limit lim ←−(∗i∈XGi, pXY : X ⊆ Y ⋐ I). We rema...

A Banach space X is asymptotically symmetric (a.s.) if for some C <∞, for all m ∈ N, for all bounded sequences (xj)j=1 ⊆ X, 1 ≤ i ≤ m, for all permutations σ of {1, . . . ,m} and all ultrafilters U1, . . . ,Um on N, lim n1,U1 . . . lim nm,Um ∥∥∥∥ m ∑ i=1 xini ∥∥∥∥ ≤ C lim nσ(1),Uσ(1) . . . lim nσ(m),Uσ(m) ∥∥∥∥ m ∑

We explore the possible application of linear covariance-based (LCB) filtering to line-intensity mapping (LIM) signal reconstructions. Originally introduced for reconstruction integrated Sachs-Wolfe effect in cosmic microwave background, LCB filter is an optimal map estimator that extends simple Wiener by leveraging external correlated data. Given a detectable strong LIM-galaxy or LIM-LIM cross...

Mammary oncogenesis is profoundly influenced by signaling pathways controlled by estrogen receptor alpha (ERalpha). Although it is known that ERalpha exerts its oncogenic effect by stimulating the proliferation of many human breast cancers through the activation of target genes, our knowledge of the underlying transcriptional mechanisms remains limited. Our published work has shown that the in ...

During spinal cord development, the LIM domains of the LIM homeodomain factor Lhx3 bind to either the LIM cofactor nuclear LIM interactor (NLI) or another LIM homeodomain factor, Isl1, assembling the tetrameric V2 interneuron-specifying Lhx3 complex (2NLI:2Lhx3) or the hexameric motor neuron-specifying Isl1-Lhx3 complex (2NLI:2Isl1:2Lhx3). However, the detailed molecular basis by which the Lhx3...

The mechanisms that regulate the development of the amygdaloid complex are as yet poorly understood. Here, we show that in the absence of the LIM-homeodomain (LIM-HD) gene Lhx2, a particular amygdaloid nucleus, the nucleus of the lateral olfactory tract (nLOT), is selectively disrupted. LIM family members are well suited for multiple roles in the development of complex structures because they p...