Loop formation between monomers in the interior of semiflexible chains describes elementary events in biomolecular folding and DNA bending. We calculate analytically the interior distance distribution function for semiflexible chains using a mean field approach. Using the potential of mean force derived from the distance distribution function we present a simple expression for the kinetics of i...

Pain is an important dimension of quality-of-life in patients with metastatic castrate-sensitive prostate cancer (mCSPC). However, it unclear if dynamic change pain over time can predict for overall survival (OS) or to radiographic progression (TTRP) these patients. This exploratory analysis LATITUDE, which men de novo mCSPC were randomized receive either ADT plus abiraterone versus alone. Info...

با توجه به رشد بالای جمعیت در جهان و نیاز اطمینان از امنیت غذایی، افزایش تولید واحد سطح محصولات زراعی به‌منزلة راهبردی اساسی حل مسئلة تأمین غذا به‌شمار می‌رود. سوی دیگر، وجود محدودیت زیرکشت پایین‌بودن میانگین عملکرد برخی کشاورزی مانند گندم کشور، محصول می‌تواند راهکاری عملی پاسخ کشور محسوب شود. یکی مهم‌ترین بیماری‌های فوزاریوم است که، نقش پیش‌بینی این بیماری جلوگیری کاهش بهره‌وری محصول، مدل‌هایی...

There are no detailed accounts of the connexions and branching of the axons of neurons in the pedal ganglia of opisthobranchs. Most of the experiments on these ganglia have been limited to cutting and stimulating nerve trunks, and using these techniques, Frohlich (1910) demonstrated the role of the pedal ganglia in inhibiting the tonic contraction of the isolated foot of Aplysia limacina. Ten C...

PURPOSE To examine the influence of exercise intensity on postprandial health outcomes in adolescents when exercise is accumulated throughout the day. METHODS 19 adolescents (9 male, 13.7±0.4 years old) completed three 1-day trials in a randomised order: (1) rest (CON); or four bouts of (2) 2×1 min cycling at 90% peak power with 75 s recovery (high-intensity interval exercise; HIIE); or (3) c...

OBJECTIVE Changes in insulin sensitivity (IS) and insulin secretion occur with perturbations in energy balance and glycemic load (GL) of the diet that may precede the development of insulin resistance and hyperinsulinemia. Determinants of changes in IS and insulin secretion with weight cycling in non-obese healthy subjects remain unclear. METHODS In a 6wk controlled 2-stage randomized dietary...

The excitatory post-synaptic potentials (EPSPs) of molluscan neurones presumably result, as in other cells (Fatt & Katz, 1951; Eccles, 1964), from an increase in membrane conductance to one or more ions which tends to drive the membrane toward a reversal potential near zero. Consequently, membrane hyperpolarization should increase the amplitude of an EPSP, whereas depolarization should have the...

Much of the recent work on the giant cells in the central nervous system of gastropods is related to the activity and the electrical properties of individual cells (Tauc, 1955, 1957, i960, 1962; Arvanitaki & Chalazonitis, 1956; Kerkut & Walker, 1961). Although this has greatly advanced our understanding of the physiology and pharmacology of the individual neurons, there is still much to be lear...