OBJECTIVE To clarify whether biochemical markers of collagen type III and I metabolism show alterations in type I diabetic subjects with Dupuytren's disease (DD) compared to those without DD. METHODS DD was assessed in a total of 28 type I diabetic subjects, mean age 43.4 +/- 9.5 (SD) and duration of diabetes 25.2 +/- 9.7 years. Concentrations of aminoterminal propeptide of type III procollag...

BACKGROUND Left ventricular diastolic dysfunction (DD) is common after myocardial infarction (MI) despite preservation of left ventricular ejection fraction, yet it remains unclear how or whether DD affects cardiac hemodynamics with stress. METHODS AND RESULTS Invasive hemodynamic exercise testing was performed in 46 patients with a recent MI and left ventricular ejection fraction >45% and in...

فرزند‌پروری پس از طلاق یکی تکالیف حساس پیش روی والدین مُطلقه، و عوامل مؤثر در سلامت روانی فرزندان به شمار می‌آید. هدف این مطالعه کشف تبیین تجارب زیسته‌ هم‌والدگری است. روش کیفی با استفاده پدیدارشناسی توصیفی انجام شد. جامعه پژوهش شامل کلیه‌ والدینی بود که تجربه‌ فرزندپروری را داشته‌اند. برای تعیین حجم نمونه معیار اشباع داده شد نمونه‌گیری هدفمند تعداد 12 نفر (زن، مرد) انتخاب شدند مورد مصاحبه‌ نیمه...

Darier disease (DD) is a rare dominantly inherited genodermatosis characterized by loss of intercellular adhesion (acantholysis) and abnormal keratinization. DD is often difficult to manage. Numerous treatments have reportedly been used for the treatment of DD, with limited success. Systemic retinoids are considered the drug of choice for treating DD. However, their use is limited by potential ...

OBJECTIVE The benefits of cochlear implantation for children with developmental delays (DD) often are unclear. We compared cognition, adaptive behavior, familial stress, and communication in children with and without DD. STUDY DESIGN Retrospective review. SETTING Two tertiary care pediatric hospitals. PATIENTS Two hundred four children who underwent cochlear implantation assessed before a...

Diastolic depolarization (DD) of atrial myocytes can lead to spontaneous action potentials (APs) and, potentially, atrial tachyarrhythmias. This study examined the hypotheses that 1) a slowly inactivating component of the Na(+) current (referred to as late I(Na)) may contribute to DD and initiate AP firing and that 2) blocking late I(Na) will reduce spontaneous and induced firing of APs by atri...

is the most fundamental example. Much like in the classical case of the Lebesgue di erentiation theorem, pointwise convergence almost everywhere of the inverse Fourier transform to f ∈ Lp (R) can be reduced to Lp bounds for the maximal operator C. Weak type L2 bounds were rst obtained by Lennart Carleson in 1966 [8], thus providing a surprising a rmative solution to the question of pointwise co...