a b s t r a c t introduction: in an oddball experiment, the context in which novel stimuli are presented affects characteristics of novelty p3, i.e. as long as there is a difficult task in which the difference between standard and target stimuli is small, recurrent presentation of a highly discrepant stimulus can lead to p300 highly similar to novelty p3. effect of stimulus properties on p300 h...

A major cause of fasting hyperglycemia in diabetes mellitus is unregulated hepatic glucose production (HGP). Insulin suppresses HGP by phosphorylating CBP and disassembling the CREB-CBP complex from gluconeogenic genes. p300 is closely related to CBP; but in contrast to CBP, p300 binds constitutively to CREB due to the absence of phosphorylation site found in CBP. In a phosphorylation-competent...

This paper investigates P300 features extracted through wavelet transform for BCI systems. Feature extraction is one of the key issues of signal processing for P300 based brain-computer interface systems (BCI). This paper examines and highlights the significance of using wavelets in P300 based BCI systems. We also mention various methods of feature extraction from P300 signals. The analysis sug...

The p300 and CBP transcriptional coactivator paralogs (p300/CBP) regulate a variety of different cellular pathways, in part, by acetylating histones and more than 70 non-histone protein substrates. Mutation, chromosomal translocation, or other aberrant activities of p300/CBP are linked to many different diseases, including cancer. Because of its pleiotropic biological roles and connection to di...

The present study investigated one of the characteristics of No-go-related brain activity during somatosensory Go/No-go paradigms, by manipulating the stimulus site and response hand. Somatosensory event-related potentials (ERPs) were recorded in ten right-handed subjects. Electrical stimulation was delivered to the second and fifth digit of one hand, and the subjects had to respond to a Go sti...

Transcriptional coactivators such as p300 and CREB-binding protein (CBP) function as important elements in the transcription factor network, linking individual transactivators via protein-protein interactions to the basal transcriptional machinery. We have investigated whether p300 plays a role in transactivation mediated by C/EBPbeta, a conserved member of the C/EBP family. We show that C/EBPb...

Sustained hyperglycemia in diabetes causes alteration of a large number of transcription factors and mRNA transcripts, leading to tissue damage. We investigated whether p300, a transcriptional coactivator with histone acetyl transferase activity, regulates glucose-induced activation of transcription factors and subsequent upregulation of vasoactive factors and extracellular matrix (ECM) protein...

Transcriptional coactivator p300 is required for embryonic development and cell proliferation. Valproic acid, a histone deacetylase inhibitor, is widely used in the therapy of epilepsy and bipolar disorder. However, it has intrinsic teratogenic activity through unidentified mechanisms. We report that valproic acid stimulates proteasome-dependent p300 degradation through augmentation of gene exp...

P300 latency is commonly thought to provide a chronometric index of the duration of perceptual processing. Because the evidence in favor of this assumption is controversial, we examined whether P300 latency is influenced by perceptual processes, response selection, and by motoric processes in two experiments using a two-choice spatial stimulus-response compatibility (SRC) task. Both experiments...

E1A binding protein (p300) and its paralog CREB (CBP or CREBBP) are ubiquitously expressed histone acetyl transferases (HAT) that act by scaffolding as co-activator enhancer of different transcription factors like HIF1a, BRCA-1, p53, c-Myc, Estrogen receptor (ER) Androgen (AR). CBP p300 multidomain proteins harbour functional units imperative for chromatin remodelling Bromodomain (BD), Histone ...