Scaffold/matrix-associated region (S/MAR) sequences are DNA regions that are attached to the nuclear matrix, and participate in many cellular processes. The nuclear matrix is a complex structure consisting of various elements. In this paper we compared frequencies of simple nucleotide motifs in S/MAR sequences and in sequences extracted directly from various nuclear matrix elements, such as nuc...

Teff, Karen L., Abass Alavi, Jergin Chen, Michael Pourdehnad, and Raymond R. Townsend. Muscarinic blockade inhibits gastric emptying of mixed-nutrient meal: effects of weight and gender. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R707–R714, 1999.—We compared the vagal contribution to gastric emptying in lean and obese subjects by monitoring gastric emptying of a meal during...

Billington, Charlotte K., Sunil K. Joseph, Caroline Swan, Mark G. H. Scott, Timothy M. Jobson, and Ian P. Hall. Modulation of human airway smooth muscle proliferation by type 3 phosphodiesterase inhibition. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L412–L419, 1999.— Elevation in cell cAMP content can inhibit mitogenic signaling in cultured human airway smooth muscle (HASM) cells. We st...

Watts, Stephanie W., and Gregory D. Fink. 5-HT2Breceptor antagonist LY-272015 is antihypertensive in DOCAsalt-hypertensive rats. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H944–H952, 1999.—We previously demonstrated a change in the receptors mediating 5-hydroxytryptamine (5-HT)-induced contraction in arteries of deoxycorticosterone acetate (DOCA)-salt-hypertensive rats. Specifically, contra...

Ray, Ramesh M., Barbara J. Zimmerman, Shirley A. McCormack, Tarun B. Patel, and Leonard R. Johnson. Polyamine depletion arrests cell cycle and induces inhibitors p21Waf1/Cip1, p27Kip1, and p53 in IEC-6 cells. Am. J. Physiol. 276 (Cell Physiol. 45): C684–C691, 1999.—The polyamines spermidine and spermine and their precursor putrescine are intimately involved in and are required for cell growth a...

Hardt, Stefan E., Armin Just, Raffi Bekeredjian, Wolfgang Kübler, Hartmut R. Kirchheim, and Helmut F. Kuecherer. Aortic pressure-diameter relationship assessed by intravascular ultrasound: experimental validation in dogs. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1078– H1085, 1999.—Intravascular ultrasound (IVUS) has emerged as an important diagnostic method for evaluating vessel diameter...

Marples, David, Jørgen Frøkiaer, and Søren Nielsen. Long-term regulation of aquaporins in the kidney. Am. J. Physiol. 276 (Renal Physiol. 45): F331–F339, 1999.—The discovery of the aquaporin family of water channels has greatly improved our understanding of how water crosses epithelial cells, particularly in the kidney. The study of the mechanisms involved in the regulation of collecting duct w...

Francis, Noelle,Alain Cohen-Solal, and Damien Logeart. Peripheral muscle ergoreceptors and ventilatory response during exercise recovery in heart failure. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H913–H917, 1999.— Recent studies have suggested that the increased ventilatory response during exercise in patients with chronic heart failure was related to the activation of muscle metaborecept...

Mukkamala, Ramakrishna, Joanne M. Mathias, Thomas J. Mullen, Richard J. Cohen, and Roy Freeman. System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R905–R912, 1999.—We applied cardiovascular system identification (CSI) to characterize closed-loop cardiovascular regulation in patien...

Bestle, Morten Heiberg, Niels Vidiendal Olsen, Poul Christensen, Benny Vittrup Jensen, and Peter Bie. Cardiovascular, endocrine, and renal effects of urodilatin in normal humans. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R684–R695, 1999.—Effects of urodilatin (5, 10, 20, and 40 ng·kg21 ·min21) infused over 2 h on separate study days were studied in eight normal subjects wi...